Lilja-Maula L I O, Laurila H P, Syrjä P, Lappalainen A K, Krafft E, Clercx C, Rajamäki M M
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
J Vet Intern Med. 2014 Mar-Apr;28(2):379-85. doi: 10.1111/jvim.12281. Epub 2014 Jan 13.
Idiopathic pulmonary fibrosis (IPF) is an incurable interstitial lung disease occurring mainly in West Highland White Terriers (WHWTs). The effects of IPF on survival and on exercise tolerance in WHWTs are unknown.
To evaluate survival, prognostic factors, and exercise tolerance in WHWTs with IPF.
Privately owned WHWTs; 15 with IPF and 11 healthy controls.
Prospective case-control study conducted in 2007-2012. For survival, descriptive statistics and Kaplan-Meier (KM) survival curves with Cox proportional hazard ratios were performed. For the prognostic factor study, KM curves, Cox regression analysis, and logistic regression models were used. The 6-minute walk test (6MWT) was used for measurement of exercise tolerance.
The median IPF-specific survival of deceased WHWTs (7/15) with IPF was 32 (range 2-51) months from onset of clinical signs. The risk of death from birth in WHWTs with IPF in age-adjusted Cox model was significantly higher (hazard ratio 4.6; 95% confidence interval 1.05-19.74, P = .04) than in control WHWTs. No significant prognostic factors were identified. In 6MWT, WHWTs with IPF walked a shorter distance, median 398 m (range 273-519 m), than healthy controls, median 492 m (420-568 m), P = .05, and the partial pressure of oxygen in arterial blood in diseased dogs had a moderate positive correlation with walking distance (Kendall's tau-b = 0.69, P = .06).
IPF had a negative impact on life expectancy, but individual survival varied considerably. 6MWT proved to be a well-tolerated, noninvasive test to evaluate exercise tolerance.
特发性肺纤维化（IPF）是一种主要发生在西部高地白梗（WHWTs）身上的无法治愈的间质性肺病。IPF对WHWTs的生存及运动耐量的影响尚不清楚。
评估患有IPF的WHWTs的生存情况、预后因素及运动耐量。
私人饲养的WHWTs；15只患有IPF，11只为健康对照。
2007年至2012年进行的前瞻性病例对照研究。对于生存情况，进行描述性统计及带有Cox比例风险比的Kaplan-Meier（KM）生存曲线分析。对于预后因素研究，使用KM曲线、Cox回归分析及逻辑回归模型。采用6分钟步行试验（6MWT）测量运动耐量。
患有IPF的死亡WHWTs（7/15）从临床症状出现起的IPF特异性生存中位数为32（范围2-51）个月。在年龄调整的Cox模型中，患有IPF的WHWTs出生时的死亡风险显著高于对照WHWTs（风险比4.6；95%置信区间1.05-19.74，P = 0.04）。未发现显著的预后因素。在6MWT中，患有IPF的WHWTs行走的距离较短，中位数为398米（范围273-519米），而健康对照的中位数为492米（420-568米），P = 0.05，患病犬动脉血中的氧分压与行走距离呈中度正相关（Kendall's tau-b = 0.69，P = 0.06）。
IPF对预期寿命有负面影响，但个体生存差异很大。6MWT被证明是一种耐受性良好的非侵入性试验，用于评估运动耐量。
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