余甘子可改善链脲佐菌素诱导的 2 型糖尿病模型大鼠的血糖状态和氧化应激。
Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats.
机构信息
Department of Genetic Engineering and Biotechnology, Jessore Science and Technology University, Jessore, Bangladesh.
Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh.
出版信息
Asian Pac J Trop Med. 2014 Jan;7(1):21-5. doi: 10.1016/S1995-7645(13)60185-6.
OBJECTIVE
To evaluate the antidiabetic and antioxidant potential of Emblica officinalis (E. officinalis) fruit on normal and type 2 diabetic rats.
METHODS
Type 2 diabetes was induced into the male Long-Evans rats. The rats were divided into nine groups including control groups receiving water, type 2 diabetic controls, type 2 diabetic rats treated with glibenclamide (T2GT) and type 2 diabetic rats treated with aqueous extract of fruit pulp of E. officinalis. They were fed orally for 8 weeks with a single feeding. Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day. Packed red blood cells and serum were used for evaluating different biochemical parameters.
RESULTS
Four weeks administration of aqueous extract of E. officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant (P<0.007) reduction in fasting serum glucose level compared to 0 day. Triglycerides decreased by 14% but there was no significant change in serum ALT, creatinine, cholesterol and insulin level in any group. Furthermore, reduced erythrocyte malondialdehyde level showed no significant change (P<0.07) but reduced glutathione content was found to be increased significantly (P<0.05).
CONCLUSIONS
The aqueous extract of E. officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.
目的
评估余甘果（余甘果）的果实对正常和 2 型糖尿病大鼠的降血糖和抗氧化潜力。
方法
将 2 型糖尿病诱导入雄性长耳大鼠。将大鼠分为 9 组，包括接受水的对照组、2 型糖尿病对照组、接受格列本脲（T2GT）治疗的 2 型糖尿病大鼠和接受余甘果果肉水提物治疗的 2 型糖尿病大鼠。它们每天口服给药一次，共 8 周。在第 0 天和第 28 天通过切断尾尖，第 56 天通过断头采血。使用红细胞和血清评估不同的生化参数。
结果
余甘果水提物连续给药 4 周可改善 2 型大鼠的口服糖耐量，连续给药 8 周后空腹血清葡萄糖水平较第 0 天显著降低（P<0.007）。甘油三酯降低 14%，但各组血清丙氨酸转氨酶、肌酐、胆固醇和胰岛素水平均无显著变化。此外，红细胞丙二醛水平降低不显著（P<0.07），但还原型谷胱甘肽含量显著增加（P<0.05）。
结论
余甘果的水提取物具有有希望的降血糖和抗氧化特性，可考虑在药物开发的进一步临床研究中使用。
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