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1
Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin.小鼠H-2k限制性细胞毒性T细胞可识别甲型流感病毒A/PR/8/34血凝素HA1和HA2亚基中的抗原决定簇。
J Exp Med. 1987 Sep 1;166(3):693-701. doi: 10.1084/jem.166.3.693.
2
Characterization of two distinct major histocompatibility complex class I Kk-restricted T-cell epitopes within the influenza A/PR/8/34 virus hemagglutinin.甲型流感病毒A/PR/8/34血凝素中两个不同的主要组织相容性复合体I类Kk限制性T细胞表位的特征分析
J Virol. 1991 Oct;65(10):5401-9. doi: 10.1128/JVI.65.10.5401-5409.1991.
3
HA2 subunit of influenza A H1 and H2 subtype viruses induces a protective cross-reactive cytotoxic T lymphocyte response.甲型H1和H2亚型流感病毒的HA2亚基可诱导产生具有保护性的交叉反应性细胞毒性T淋巴细胞应答。
J Immunol. 1988 Feb 15;140(4):1264-8.
4
On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes.关于甲型流感病毒血凝素跨膜锚定序列在I类主要组织相容性复合体限制的、血凝素特异性细胞毒性T淋巴细胞识别靶细胞中的作用。
J Exp Med. 1987 Sep 1;166(3):678-92. doi: 10.1084/jem.166.3.678.
5
Cytolytic T lymphocyte and antibody responses to synthetic peptides of influenza virus hemagglutinin.细胞溶解性T淋巴细胞及对流感病毒血凝素合成肽的抗体反应。
J Immunol. 1984 Oct;133(4):2194-201.
6
Influenza A virus-specific H-2d restricted cross-reactive cytotoxic T lymphocyte epitope(s) detected in the hemagglutinin HA2 subunit of A/Udorn/72.在A/Udorn/72的血凝素HA2亚基中检测到甲型流感病毒特异性的H-2d限制性交叉反应性细胞毒性T淋巴细胞表位。
Virology. 1995 Dec 20;214(2):445-52. doi: 10.1006/viro.1995.0055.
7
Class I MHC-restricted recognition of cells expressing a gene encoding a 41 amino acid product of the influenza hemagglutinin.I类主要组织相容性复合体限制对表达编码流感血凝素41个氨基酸产物基因的细胞的识别。
J Immunol. 1988 Nov 15;141(10):3324-8.
8
Diversity of the class II (I-Ak/I-Ek)-restricted T cell repertoire for influenza hemagglutinin and antigenic drift. Six nonoverlapping epitopes on the HA1 subunit are defined by synthetic peptides.II类（I-Ak/I-Ek）限制性T细胞库对流感血凝素的多样性及抗原漂移。HA1亚基上的六个非重叠表位由合成肽段确定。
J Exp Med. 1989 Aug 1;170(2):383-97. doi: 10.1084/jem.170.2.383.
9
A region of the influenza A/NT/60/68 PB2 protein containing an antigenic determinant recognized by murine H-2Dd restricted cytotoxic T lymphocytes.甲型流感病毒/NT/60/68 PB2蛋白的一个区域，该区域含有一个可被小鼠H-2Dd限制性细胞毒性T淋巴细胞识别的抗原决定簇。
Virology. 1988 Nov;167(1):261-8. doi: 10.1016/0042-6822(88)90076-1.
10
Cytotoxic T lymphocytes recognize a cross-reactive epitope on the transmembrane region of influenza H1 and H2 hemagglutinins.细胞毒性T淋巴细胞识别甲型流感病毒H1和H2血凝素跨膜区域上的一个交叉反应表位。
Viral Immunol. 1989 Fall;2(3):163-73. doi: 10.1089/vim.1989.2.163.

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Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.利用 RNA 介导的伴侣蛋白将流感血凝素组装成具有免疫相关性的构象。
FASEB J. 2018 May;32(5):2658-2675. doi: 10.1096/fj.201700747RR. Epub 2018 Jan 2.
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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.CD147与乳酸转运蛋白MCT1和MCT4紧密相关，并促进它们在细胞表面的表达。
EMBO J. 2000 Aug 1;19(15):3896-904. doi: 10.1093/emboj/19.15.3896.
3
Presentation of a cytosolic antigen by major histocompatibility complex class II molecules requires a long-lived form of the antigen.主要组织相容性复合体II类分子呈递胞质抗原需要抗原的长寿命形式。
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14692-7. doi: 10.1073/pnas.93.25.14692.
4
A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection.含有gp120结合位点的大鼠CD4突变体介导1型人类免疫缺陷病毒感染。
J Exp Med. 1993 Apr 1;177(4):949-54. doi: 10.1084/jem.177.4.949.
5
MHC ligands and peptide motifs: first listing.主要组织相容性复合体（MHC）配体与肽基序：首次列表。
Immunogenetics. 1995;41(4):178-228. doi: 10.1007/BF00172063.
6
Processing of major histocompatibility class I-restricted antigens in the endoplasmic reticulum.内质网中主要组织相容性复合体I类限制抗原的加工
J Exp Med. 1995 Apr 1;181(4):1481-91. doi: 10.1084/jem.181.4.1481.
7
T cell recognition of an HLA-A2-restricted epitope derived from a cleaved signal sequence.T细胞对源自裂解信号序列的HLA - A2限制性表位的识别。
J Exp Med. 1994 Nov 1;180(5):1989-94. doi: 10.1084/jem.180.5.1989.
8
The role of beta-hydroxyaspartate and adjacent carboxylate residues in the first EGF domain of human factor IX.β-羟基天冬氨酸和相邻羧基残基在人凝血因子IX首个表皮生长因子结构域中的作用。
EMBO J. 1988 Jul;7(7):2053-61. doi: 10.1002/j.1460-2075.1988.tb03045.x.
9
Characterization of two distinct major histocompatibility complex class I Kk-restricted T-cell epitopes within the influenza A/PR/8/34 virus hemagglutinin.甲型流感病毒A/PR/8/34血凝素中两个不同的主要组织相容性复合体I类Kk限制性T细胞表位的特征分析
J Virol. 1991 Oct;65(10):5401-9. doi: 10.1128/JVI.65.10.5401-5409.1991.
10
Overlapping cytotoxic T-lymphocyte and B-cell antigenic sites on the influenza virus H5 hemagglutinin.流感病毒H5血凝素上重叠的细胞毒性T淋巴细胞和B细胞抗原位点。
J Virol. 1990 Dec;64(12):6246-51. doi: 10.1128/JVI.64.12.6246-6251.1990.

本文引用的文献

1
Stimulation of anti-influenza cytolytic T lymphocytes by CNBr cleavage fragments of the viral hemagglutinin.病毒血凝素的溴化氰裂解片段对抗流感细胞溶解T淋巴细胞的刺激作用。
J Immunol. 1981 Sep;127(3):1122-5.
2
Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.氨和氯喹引起的巨噬细胞抗原分解代谢减少与抗原呈递给T细胞的抑制相关。
Proc Natl Acad Sci U S A. 1982 Jan;79(1):175-8. doi: 10.1073/pnas.79.1.175.
3
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA.使用M13衍生载体的寡核苷酸定向诱变：在任何DNA片段中产生点突变的高效通用方法。
Nucleic Acids Res. 1982 Oct 25;10(20):6487-500. doi: 10.1093/nar/10.20.6487.
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Cytotoxic T-cell immunity to influenza.针对流感的细胞毒性T细胞免疫
N Engl J Med. 1983 Jul 7;309(1):13-7. doi: 10.1056/NEJM198307073090103.
5
Isolation and characterization of a CNBr cleavage peptide of influenza viral hemagglutinin stimulatory for mouse cytolytic T lymphocytes.流感病毒血凝素的一种对小鼠细胞毒性T淋巴细胞有刺激作用的CNBr裂解肽的分离与鉴定
J Immunol. 1983 May;130(5):2386-91.
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Immunogenic properties of the small chain HA2 of the haemagglutinin of influenza viruses.流感病毒血凝素小链HA2的免疫原性特性
J Gen Virol. 1984 Jan;65 ( Pt 1):173-83. doi: 10.1099/0022-1317-65-1-173.
7
Recombinant vaccinia virus primes and stimulates influenza haemagglutinin-specific cytotoxic T cells.重组痘苗病毒引发并刺激流感血凝素特异性细胞毒性T细胞。
Nature. 1984;311(5986):578-9. doi: 10.1038/311578a0.
8
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes.表达外源基因的感染性痘苗病毒重组体的生产和选择通用方法。
J Virol. 1984 Mar;49(3):857-64. doi: 10.1128/JVI.49.3.857-864.1984.
9
Complete nucleotide sequence of the haemagglutinin gene from a human influenza virus of the Hong Kong subtype.一株香港亚型人流感病毒血凝素基因的完整核苷酸序列
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10
Characterization of the murine TH response to influenza virus hemagglutinin: evidence for three major specificities.小鼠对流感病毒血凝素的TH反应特征：三种主要特异性的证据。
J Immunol. 1984 Dec;133(6):3371-7.

小鼠H-2k限制性细胞毒性T细胞可识别甲型流感病毒A/PR/8/34血凝素HA1和HA2亚基中的抗原决定簇。

Mouse H-2k-restricted cytotoxic T cells recognize antigenic determinants in both the HA1 and HA2 subunits of the influenza A/PR/8/34 hemagglutinin.

作者信息

Gould K G, Scotney H, Townsend A R, Bastin J, Brownlee G G

出版信息

J Exp Med. 1987 Sep 1;166(3):693-701. doi: 10.1084/jem.166.3.693.

DOI:10.1084/jem.166.3.693
PMID:2442286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188694/
Abstract

We have constructed two chimeric influenza hemagglutinin (HA) genes in which the HA1 and HA2 subunits of the HA molecule have been interchanged between influenza A/PR/8/34 (H1 subtype) and A/NT/60/68 (H3 subtype). These genes were used to construct recombinant vaccinia viruses that expressed intact chimeric HA. These recombinant viruses were used to test whether murine CTL recognize antigenic determinants in either the HA1, HA2, or both subunits. We found that both subunits of the HA molecule contain determinants for CTL. This implies that CTL have, at least in part, separate antigenic determinants from B lymphocytes, which recognize mainly epitopes within the HA1 subunit.

摘要

我们构建了两个嵌合流感血凝素（HA）基因，其中HA分子的HA1和HA2亚基在甲型流感病毒A/PR/8/34（H1亚型）和A/NT/60/68（H3亚型）之间进行了互换。这些基因被用于构建表达完整嵌合HA的重组痘苗病毒。这些重组病毒被用于测试小鼠细胞毒性T淋巴细胞（CTL）是否识别HA1、HA2或两个亚基中的抗原决定簇。我们发现HA分子的两个亚基都含有CTL的决定簇。这意味着CTL至少部分具有与B淋巴细胞不同的抗原决定簇，B淋巴细胞主要识别HA1亚基内的表位。