D'Silva Shaloom, Sumathi M K, Balaji N, Shetty Nisha K N, Pramod K M, Cheeramelil Jacob
Doha, Qatar.
Department of Oral & Maxillofacial Pathology, Teerthankar Mahaveer Dental College and Research Centre, Teerthankar Mahaveer University, Moradabad, Uttar Pradesh, India.
J Int Oral Health. 2013 Dec;5(6):42-8. Epub 2013 Dec 26.
Calretinin a 29-kDa calcium binding protein is expressed widely in normal human tissue and tumours including amelobastoma. The objective of this study was to determine calretinin expression in heamatoxylin and eosin diagnosed cases of ameloblastoma and non-neoplastic odontogenic cysts.
MATERIALS & METHODS: The lining epithelium in 3 cases of radicular cysts, 5 cases of odontogenic keratocysts, 5 cases of dentigerous cysts and 11 cases of ameloblastomas were examined for expression of calretinin.
No positive epithelial staining was observed in radicular and dentigerous cysts. In comparison, however 100% of cases of ameloblastomas and 40% of cases of odontogenic karatocysts showed positive calretinin expression.
Calretinin may be a specific immunohistochemical marker for ameloblastoma. If there is any possible relation between calretinin expression and neural origin of the odontogenic epithelium and its neoplastic transformation and if calretinin could be used as an early marker to predict the tendency of neoplastic change of odontogenic epithelium could be answered through further researches. How to cite this article: D'Silva S, Sumathi MK, Balaji N, Shetty NK, Pramod KM, Cheeramelil J. Evaluation of Calretinin expression in Ameloblastoma and Non-Neoplastic Odontogenic Cysts - An immunohistochemical study. J Int Oral Health 2013; 5(6):42-8 .
钙视网膜蛋白是一种29 kDa的钙结合蛋白，在包括成釉细胞瘤在内的正常人体组织和肿瘤中广泛表达。本研究的目的是确定在苏木精和伊红染色诊断的成釉细胞瘤和非肿瘤性牙源性囊肿病例中钙视网膜蛋白的表达情况。
对3例根囊肿、5例牙源性角化囊肿、5例含牙囊肿和11例成釉细胞瘤的衬里上皮进行钙视网膜蛋白表达检测。
在根囊肿和含牙囊肿中未观察到上皮阳性染色。然而，相比之下，100%的成釉细胞瘤病例和40%的牙源性角化囊肿病例显示钙视网膜蛋白表达阳性。
钙视网膜蛋白可能是成釉细胞瘤的一种特异性免疫组化标志物。钙视网膜蛋白表达与牙源性上皮的神经起源及其肿瘤转化之间是否存在任何可能的关系，以及钙视网膜蛋白是否可作为预测牙源性上皮肿瘤变化倾向的早期标志物，可通过进一步研究来解答。如何引用本文：D'Silva S, Sumathi MK, Balaji N, Shetty NK, Pramod KM, Cheeramelil J. 成釉细胞瘤和非肿瘤性牙源性囊肿中钙视网膜蛋白表达的评估 - 一项免疫组化研究。《国际口腔健康杂志》2013年；5(6):42 - 8 。
