Yu Yi, Su Lin, Wang Xinqiong, Wang Xiaojin, Xu Chundi
Department of Pediatrics, Rui Jin Hospital, School of Medicine, Shanghai JiaoTong University, China.
Intern Med. 2014;53(2):83-8. doi: 10.2169/internalmedicine.53.0918. Epub 2012 Mar 1.
H. pylori infection in children has a high prevalence worldwide. The disease can cause progressive gastric mucosal inflammation, as verified in animal models. However, data from large-scale clinical studies are limited.
We examined 1,634 Chinese children with upper gastrointestinal discomfort using endoscopy. The clinical and pathological data of the patients were analyzed.
A total of 524 (32.1%) patients were infected with H. pylori, and the prevalence of H. pylori infection increased with age. The H. pylori-infected patients exhibited a significantly higher prevalence of active inflammation (26.9% vs. 4.1%), lymphoid follicle formation (18.5% vs. 4.6%) and marked lymphocyte infiltration (19.7% vs. 5.6%). The H. pylori-infected patients also exhibited a significantly higher prevalence of moderate to marked chronic superficial gastritis (41.9% vs. 9.2%) and moderate chronic atrophic gastritis (21.7% vs. 2.6%) than the uninfected patients (p<0.01).
H. pylori infection is associated with the degree of gastric mucosal inflammation and the severity of different types of chronic gastritis.
幽门螺杆菌感染在全球儿童中具有较高的患病率。在动物模型中已证实，该疾病可导致进行性胃黏膜炎症。然而，大规模临床研究的数据有限。
我们对1634名有上消化道不适症状的中国儿童进行了内镜检查。对患者的临床和病理数据进行了分析。
共有524名（32.1%）患者感染了幽门螺杆菌，幽门螺杆菌感染率随年龄增长而升高。幽门螺杆菌感染患者的活动性炎症（26.9%对4.1%）、淋巴滤泡形成（18.5%对4.6%）和明显的淋巴细胞浸润（19.7%对5.6%）患病率显著更高。幽门螺杆菌感染患者的中度至重度慢性浅表性胃炎（41.9%对9.2%）和中度慢性萎缩性胃炎（21.7%对2.6%）患病率也显著高于未感染患者（p<0.01）。
幽门螺杆菌感染与胃黏膜炎症程度及不同类型慢性胃炎的严重程度相关。
