双稳态钙结合蛋白回路对大脑可塑性至关重要。
Bistable parvalbumin circuits pivotal for brain plasticity.
机构信息
Center for Brain Science, Department of Molecular & Cellular Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA; F.M. Kirby Neurobiology Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Cell. 2014 Jan 16;156(1-2):17-9. doi: 10.1016/j.cell.2013.12.034.
Abstract
Experience shapes brain function throughout life to varying degrees. In a recent issue of Nature, Donato et al. identify reversible shifts in focal parvalbumin cell state during adult learning, placing it on a mechanistic continuum with developmental critical periods. A disinhibitory microcircuit controls the plasticity switch to modulate memory formation.
摘要
经验在不同程度上塑造了整个生命过程中的大脑功能。在最近一期的《自然》杂志上，Donato 等人确定了成年学习过程中局部钙蛋白细胞状态的可逆转变，并将其置于与发育关键期具有相同机制的连续体上。一种去抑制性的微电路控制着可塑性的转变，从而调节记忆的形成。
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本文引用的文献
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