Rowe D, Griffiths M, Stewart J, Novick D, Beverley P C, Isenberg D A
Department of Morbid Anatomy, School of Medicine, University College, London.
Ann Rheum Dis. 1987 Aug;46(8):580-6. doi: 10.1136/ard.46.8.580.
Labial biopsy specimens from eight patients with primary Sjögren's syndrome (SS), 10 patients with secondary SS, and three healthy controls were studied with monoclonal antibodies identifying HLA class I and class II antigens; interferon-alpha, beta, and gamma; interleukin 2 (IL2); and the IL2 receptor (Tac) among others. In the normal biopsy specimens there was evidence of HLA class I and, to a lesser extent, class II antigens in both ducts and acini, though this was much less marked than in the Sjögren's biopsy specimens. Interferon-gamma staining, but not interferon-alpha or beta, was also considerably enhanced in the biopsy specimens from the patients with Sjögren's syndrome. These data support the view that in Sjögren's syndrome the release of interferon-gamma may be involved in the induction of class II determinants. Our observations were broadly similar in both primary and secondary Sjögren's syndrome except that patients with primary Sjögren's syndrome tended to have more diffusely scattered T lymphocytes.
对8例原发性干燥综合征（SS）患者、10例继发性SS患者的唇腺活检标本以及3例健康对照者的唇腺活检标本进行了研究，采用单克隆抗体鉴定HLA Ⅰ类和Ⅱ类抗原、α干扰素、β干扰素、γ干扰素、白细胞介素2（IL2）以及IL2受体（Tac）等。在正常活检标本中，导管和腺泡均有HLA Ⅰ类抗原表达，HLA Ⅱ类抗原表达较少，不过其表达程度远低于干燥综合征活检标本。干燥综合征患者活检标本中的γ干扰素染色显著增强，而α干扰素或β干扰素染色则未增强。这些数据支持以下观点：在干燥综合征中，γ干扰素的释放可能参与了Ⅱ类决定簇的诱导。我们在原发性和继发性干燥综合征中的观察结果大致相似，只是原发性干燥综合征患者的T淋巴细胞往往呈更广泛的散在分布。
