Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults.

OBJECTIVE

Investigate the latent cytomegalovirus (CMV) infection as a biomarker of oxidative stress and atherosclerosis.

METHODS

Latent CMV infection was diagnosed in healthy individuals with PCR-evidence of CMV DNA in peripheral leucocytes. Oxidative stress and atherosclerosis were measured by mitochondrial DNA oxidative damage index (mtDNA(ΔCT)) and intima media thickness (IMT).

RESULTS

The CMV DNA positive subjects had a higher mean mtDNA(ΔCT) and greater IMT than subjects in the control group.

CONCLUSIONS

Presence of CMV DNA in leucocytes, as a marker of latent CMV infection, was associated with increased levels of oxidative stress and subclinical atherosclerosis in healthy adults.