Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China.
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China. Email:
Chin Med J (Engl). 2014;127(3):568-73.
This article aimed to review the incidence of Helicobacter pylori (H. pylori) infection and its therapy.
Relevant articles published in English were identified by searching in PubMed from 2000 to 2013, with keywords "H. pylori". Important references from selected articles were also retrieved from Elsevier, Wiley, EBSCO, and SPRINGER. The Chinese articles published were searched from China National Knowledge Infrastructure (CNKI).
Articles about "prevalence", "gastric carcinoma", "peptic ulcer", "gastroesophageal reflux disease", "functional dyspepsia", "pathogenic mechanism", "therapy", "eradication rate", "antibiotic resistance", and "gene polymorphisms" were selected.
The decreased infection rates of H. pylori could also be linked to the changed disease spectrum, such as the decreased morbidity and recurrence rate of H. pylori-related peptic ulcer, and the increased morbidity of gastroesophageal reflux. Although different treatment regimens have been used for H. pylori infection, the H. pylori eradication rate declined gradually. Due to primary resistance to antibiotics, the gene polymorphism of host and infected strain, and the therapy regimes, H. pylori eradication became even more difficult.
The prevalence of H. pylori infection had been decreasing, but the rate of eradication failure has dramatically risen in many countries due to resistance to antibiotic. H. pylori therapy in clinical practice is becoming progressively more difficult.
本文旨在回顾幽门螺杆菌（H. pylori）感染及其治疗的发生率。
通过在 2000 年至 2013 年期间在 PubMed 中以“ H. pylori”为关键词搜索，确定了以英文发表的相关文章。还从 Elsevier、Wiley、EBSCO 和 SPRINGER 检索了从选定文章中提取的重要参考文献。从中国国家知识基础设施（CNKI）中搜索了发表的中文文章。
选择了有关“流行率”，“胃癌”，“消化性溃疡”，“胃食管反流病”，“功能性消化不良”，“发病机制”，“治疗”，“清除率”，“抗生素耐药性”和“基因多态性”的文章。
H. pylori感染率的降低也可能与疾病谱的变化有关，例如与 H. pylori相关的消化性溃疡的发病率和复发率降低，以及胃食管反流病的发病率增加。尽管已经使用了不同的治疗方案来治疗 H. pylori感染，但是 H. pylori根除率逐渐下降。由于对抗生素的原发性耐药性，宿主和感染株的基因多态性以及治疗方案，H. pylori的根除变得更加困难。
在许多国家，由于抗生素耐药性，H. pylori感染的流行率已经降低，但根除失败的比率却急剧上升。在临床实践中，H. pylori的治疗变得越来越困难。
