Hajaghamohammadi Aliakbar, Safiabadi Tali Seyyed Hossein, Samimi Rasoul, Oveisi Sonia, Kazemifar Amir Mohammad
Qazvin university of medical sciences.
Glob J Health Sci. 2014 Aug 31;7(1):235-9. doi: 10.5539/gjhs.v7n1p235.
Helicobacter pylori infection is a common chronic human bacterial infection. Triple- therapy regimen containing a proton pump inhibitor, clarithromycin, and either amoxicillin or metronidazole is commonly used as first-line treatment for its eradication. However, it may not provide the acceptable eradication rate. The present study was designed to evaluated efficacy of low dose furazolidone with amoxicillin and omeprazole for eradication of H- pylori.
MATERIALS & METHODS: One hundred twenty patients with non- ulcer dyspepsia or peptic ulcer confirmed by upper GI endoscopy, plus H- pylori infection confirmed by rapid urease test were included in the study. They were randomly divided into two groups, and then received clarithromycin, amoxicillin, and omeprazole, or furazolidone (100 mg PO bid), amoxicillin, and omeprazole. They were evaluated using urea breath test at the end of the study.
The eradication rates were 57.6% and 78.8% in clarithromycin and furazolidone groups, respectively. Their difference was statistically significant (P value 0.013). No side effect was seen in the furazolidone group.
Low dose furazolidone rather than clarithromycin can be used as low- cost and effective drug for eradication of H- pylori, in combination with amoxicillin and omeprazole.
幽门螺杆菌感染是一种常见的人类慢性细菌感染。包含质子泵抑制剂、克拉霉素以及阿莫西林或甲硝唑的三联疗法通常被用作根除幽门螺杆菌的一线治疗方法。然而，其根除率可能并不理想。本研究旨在评估低剂量呋喃唑酮联合阿莫西林和奥美拉唑根除幽门螺杆菌的疗效。
本研究纳入了120例经上消化道内镜检查确诊为非溃疡性消化不良或消化性溃疡，且经快速尿素酶试验确诊为幽门螺杆菌感染的患者。他们被随机分为两组，分别接受克拉霉素、阿莫西林和奥美拉唑，或呋喃唑酮（口服，每次100mg，每日两次）、阿莫西林和奥美拉唑治疗。研究结束时通过尿素呼气试验对他们进行评估。
克拉霉素组和呋喃唑酮组的根除率分别为57.6%和78.8%。两组差异具有统计学意义（P值为0.013）。呋喃唑酮组未见副作用。
低剂量呋喃唑酮联合阿莫西林和奥美拉唑，可作为一种低成本且有效的根除幽门螺杆菌的药物，而非克拉霉素。
