Barlati Stefano, Deste Giacomo, De Peri Luca, Ariu Cassandra, Vita Antonio
Department of Mental Health, Spedali Civili Hospital, Piazzale Spedali Civili 1, 25123 Brescia, Italy.
Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.
Schizophr Res Treatment. 2013;2013:156084. doi: 10.1155/2013/156084. Epub 2013 Dec 17.
Objectives. This study is aimed to review the current scientific literature on cognitive remediation in schizophrenia. In particular, the main structured protocols of cognitive remediation developed for schizophrenia are presented and the main results reported in recent meta-analyses are summarized. Possible benefits of cognitive remediation in the early course of schizophrenia and in subjects at risk for psychosis are also discussed. Methods. Electronic search of the relevant studies which appeared in the PubMed database until April 2013 has been performed and all the meta-analyses and review articles on cognitive remediation in schizophrenia have been also taken into account. Results. Numerous intervention programs have been designed, applied, and evaluated, with the objective of improving cognition and social functioning in schizophrenia. Several quantitative reviews have established that cognitive remediation is effective in reducing cognitive deficits and in improving functional outcome of the disorder. Furthermore, the studies available support the usefulness of cognitive remediation when applied in the early course of schizophrenia and even in subjects at risk of the disease. Conclusions. Cognitive remediation is a promising approach to improve real-world functioning in schizophrenia and should be considered a key strategy for early intervention in the psychoses.
目标。本研究旨在回顾当前关于精神分裂症认知康复的科学文献。特别介绍了为精神分裂症开发的主要结构化认知康复方案，并总结了近期荟萃分析报告的主要结果。还讨论了认知康复在精神分裂症早期病程以及精神病高危个体中的潜在益处。方法。对截至2013年4月发表于PubMed数据库的相关研究进行了电子检索，并纳入了所有关于精神分裂症认知康复的荟萃分析和综述文章。结果。为改善精神分裂症患者的认知和社会功能，已设计、应用并评估了众多干预项目。多项定量综述表明，认知康复在减少认知缺陷和改善该疾病的功能结局方面是有效的。此外，现有研究支持在精神分裂症早期病程甚至疾病高危个体中应用认知康复的有效性。结论。认知康复是改善精神分裂症患者现实世界功能的一种有前景的方法，应被视为精神病早期干预的关键策略。
