School of Chemical Engineering, Yeungnam University , Gyeongsan, 712-749, Republic of Korea.
J Nat Prod. 2014 Jan 24;77(1):168-72. doi: 10.1021/np400756g. Epub 2013 Dec 20.
Biofilm formation is closely related to bacterial infection and is also a mechanism of antimicrobial resistance. Hence, the antibiofilm approach provides an alternative to an antibiotic strategy. In this study, the antibiofilm activities of resveratrol (1) and five of its oligomers, namely, ε-viniferin (2), suffruticosol A (3), suffruticosol B (4), vitisin A (5), and vitisin B (6), were investigated against enterohemorrhagic Escherichia coli O157:H7 and Pseudomonas aeruginosa PA14. Vitisin B (6), a stilbenoid tetramer, was found to inhibit biofilm formation by the two bacteria the most effectively and at 5 μg/mL inhibited E. coli O157:H7 biofilm formation by more than 90%.
生物膜的形成与细菌感染密切相关，也是抗菌药物耐药的一种机制。因此，抗生物膜方法为抗生素策略提供了一种替代方法。在这项研究中，研究了白藜芦醇（1）及其五个低聚物，即 ε-viniferin（2）、suffruticosol A（3）、suffruticosol B（4）、vitisin A（5）和 vitisin B（6）对肠出血性大肠杆菌 O157:H7 和铜绿假单胞菌 PA14 的抗生物膜活性。发现二苯乙烯四聚体 vitisin B（6）对两种细菌的生物膜形成抑制作用最强，在 5 μg/mL 时，对大肠杆菌 O157:H7 的生物膜形成抑制率超过 90%。
