Ara Syeda Arshiya, Arora Vini, Zakaullah Syed, Raheel Syed Ahmed, Rampure Prakash, Ashraf Sajna
Department of Oral Medicine and Radiology, Al-Badar Rural Dental College and Hospital, Gulbarga, India E-mail :
Asian Pac J Cancer Prev. 2013;14(12):7075-80. doi: 10.7314/apjcp.2013.14.12.7075.
Oral submucosal fibrosis (OSMF) is one of the most prevalent premalignant conditions in India which is easy to diagnose but difficult to manage. At present it is considered as irreversible and incurable. It has also been referred to as an epidemic in India.
To correlate the frequency and duration of habits with clinical staging, functional staging and histopathological grading and to correlate the clinical and functional staging with histopathological grading.
The study included a total of 90 subjects, 80 with OSMF in the experimental group and 10 patients in the control group. Patient personal history was recorded with chewing habits, including frequency and duration of chewing. The site of keeping the quid, time duration and whether he/she swallows it or spits it were also noted. Clinical staging was done on the presence of palpable fibrous bands. Functional staging was accomplished by measuring mouth opening. Incisional biopsy was done for all the patients for histopathological examination. Histopathological grading was according to Pindborg and Sirsat.
The experimental group comprised 71 males and 9 females, the majority of which were in the age group of 21-30 years. Correlation of habits with clinical staging, functional staging and histopathological grading were significant (p<0.05). Clinical and functional staging did not correlate with histopathological grading, but the correlation of clinical and functional staging was highly significant (p<0.01).
The widespread habit of chewing gutkha is a major risk factor for OSMF, especially in the younger age group. In this study, it was found that with increase in the duration and frequency of the habit the severity of the disease increased.
口腔黏膜下纤维化（OSMF）是印度最常见的癌前病变之一，易于诊断但难以治疗。目前，它被认为是不可逆且无法治愈的。在印度，它也被称为一种流行病。
将习惯的频率和持续时间与临床分期、功能分期和组织病理学分级相关联，并将临床和功能分期与组织病理学分级相关联。
该研究共纳入90名受试者，实验组80例OSMF患者，对照组10例患者。记录患者的个人病史，包括咀嚼习惯，如咀嚼频率和持续时间。还记录了放置咀嚼物的部位、持续时间以及是否吞咽或吐出。根据可触及的纤维带进行临床分期。通过测量张口度完成功能分期。对所有患者进行切开活检以进行组织病理学检查。组织病理学分级按照平德伯格和西尔萨特的标准进行。
实验组包括71名男性和9名女性，大多数年龄在21 - 30岁之间。习惯与临床分期、功能分期和组织病理学分级的相关性显著（p<0.05）。临床和功能分期与组织病理学分级不相关，但临床和功能分期之间的相关性高度显著（p<0.01）。
嚼槟榔的广泛习惯是OSMF的主要危险因素，尤其是在年轻人群体中。在本研究中，发现随着习惯的持续时间和频率增加，疾病的严重程度也增加。
