风湿性多肌痛和巨细胞动脉炎中中间丝抗体的序贯研究。
Antibodies to intermediate filaments in polymyalgia rheumatica and giant cell arteritis: a sequential study.
作者信息
Dasgupta B, Duke O, Kyle V, Macfarlane D G, Hazleman B L, Panayi G S
机构信息
Rheumatology Unit, UMDS, Guy's Hospital, London.
出版信息
Ann Rheum Dis. 1987 Oct;46(10):746-9. doi: 10.1136/ard.46.10.746.
Abstract
Serum specimens from 35 patients with polymyalgia rheumatica and giant cell arteritis (PMR/GCA) were obtained sequentially at variable time intervals up to a year from onset of disease. These were tested for antibodies to intermediate filaments by indirect immunofluorescence using HEp2 cells as substrate. Twenty four of 35 (68%) patients' sera at onset of disease were positive at an anti-intermediate filament antibody (AIFA) titre of greater than 1/40 compared with three outs of 19 (15%) control sera. AIFA were predominantly of IgM class, and there was no significant change in AIFA titres on follow up despite clinical remission of disease.
摘要
从35例风湿性多肌痛和巨细胞动脉炎（PMR/GCA）患者中获取血清标本，在疾病发作后的长达一年的不同时间间隔内依次采集。以人喉上皮癌细胞（HEp2细胞）为底物，通过间接免疫荧光法检测这些标本中的中间丝抗体。与19份对照血清中的3份（15%）相比，35例患者中有24例（68%）在疾病发作时血清抗中间丝抗体（AIFA）滴度大于1/40呈阳性。AIFA主要为IgM类，尽管疾病临床缓解，但随访时AIFA滴度无显著变化。
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