• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population.韩国人群中 ALDH2 错义单核苷酸多态性（Glu504Lys）与良性前列腺增生的关联。
Int Neurourol J. 2013 Dec;17(4):168-73. doi: 10.5213/inj.2013.17.4.168. Epub 2013 Dec 31.
2
The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.乙醛脱氢酶2的Glu504Lys多态性与冠状动脉疾病的发生有关。
Tohoku J Exp Med. 2014 Oct;234(2):143-50. doi: 10.1620/tjem.234.143.
3
rs671 a/A Genotype is Associated with an Increased Risk of Early Onset Coronary Artery Stenosis.rs671 a/A基因型与早发性冠状动脉狭窄风险增加相关。
Int J Gen Med. 2024 May 24;17:2407-2415. doi: 10.2147/IJGM.S461004. eCollection 2024.
4
Genetic variants in 5p13.2 and 7q21.1 are associated with treatment for benign prostatic hyperplasia with the α-adrenergic receptor antagonist.5p13.2和7q21.1区域的基因变异与α-肾上腺素能受体拮抗剂治疗良性前列腺增生有关。
Aging Male. 2017 Dec;20(4):250-256. doi: 10.1080/13685538.2017.1358261. Epub 2017 Aug 8.
5
Association of BID SNPs (rs8190315 and rs2072392) and clinical features of benign prostate hyperplasia in Korean population.韩国人群中BID基因单核苷酸多态性（rs8190315和rs2072392）与良性前列腺增生临床特征的关联
J Exerc Rehabil. 2014 Dec 31;10(6):383-8. doi: 10.12965/jer.140168. eCollection 2014 Dec.
6
Nitric oxide synthase 2 gene polymorphisms are associated with prostatic volume in Korean men with benign prostatic hyperplasia.一氧化氮合酶 2 基因多态性与韩国良性前列腺增生男性的前列腺体积相关。
Asian J Androl. 2010 Sep;12(5):690-6. doi: 10.1038/aja.2010.37. Epub 2010 Jun 21.
7
SRD5A1 and SRD5A2 are associated with treatment for benign prostatic hyperplasia with the combination of 5α-reductase inhibitors and α-adrenergic receptor antagonists.SRD5A1 和 SRD5A2 与 5α-还原酶抑制剂和 α-肾上腺素能受体拮抗剂联合治疗良性前列腺增生有关。
J Urol. 2013 Aug;190(2):615-9. doi: 10.1016/j.juro.2013.03.024. Epub 2013 Mar 14.
8
The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels.ALDH2 Glu504Lys 多态性与汉族人群冠心病的相关性：与内皮细胞 ADMA 水平的关系。
Atherosclerosis. 2010 Aug;211(2):545-50. doi: 10.1016/j.atherosclerosis.2010.03.030. Epub 2010 Apr 4.
9
Association Study of Polymorphisms of Epidermal Growth Factor and Epidermal Growth Factor Receptor With Benign Prostatic Hyperplasia in a Korean Population.韩国人群中表皮生长因子和表皮生长因子受体多态性与良性前列腺增生的关联研究
Int Neurourol J. 2016 Dec;20(4):363-370. doi: 10.5213/inj.1632538.269. Epub 2016 Dec 26.
10
Acetaldehyde Dehydrogenase 2 rs671 Polymorphism Affects Hypertension Susceptibility and Lipid Profiles in a Chinese Population.乙醛脱氢酶 2 rs671 多态性影响中国人群的高血压易感性和血脂谱。
DNA Cell Biol. 2019 Sep;38(9):962-968. doi: 10.1089/dna.2019.4647. Epub 2019 Jul 30.

引用本文的文献

1
Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening.揭示肾功能不全和血瘀型良性前列腺增生的治疗靶点及预防成分：连接代谢组学、网络药理学与反向筛选
Front Pharmacol. 2025 Jun 19;16:1584766. doi: 10.3389/fphar.2025.1584766. eCollection 2025.
2
Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network.良性前列腺增生（BPH）的遗传性和全基因组关联研究在 eMERGE 网络中。
Sci Rep. 2019 Apr 15;9(1):6077. doi: 10.1038/s41598-019-42427-z.
3
Relationship Between Alcohol Consumption and Prostatic Hyperplasia According to Facial Flushing After Drinking in Korean Men.韩国男性饮酒后脸红与饮酒量和前列腺增生的关系
Korean J Fam Med. 2017 Mar;38(2):93-98. doi: 10.4082/kjfm.2017.38.2.93. Epub 2017 Mar 22.
4
The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study.肿瘤代谢在前列腺癌进展和致命性疾病中的驱动作用：一项巢式病例对照研究的结果
Cancer Metab. 2016 Dec 7;4:22. doi: 10.1186/s40170-016-0161-9. eCollection 2016.
5
SPINK1 Promoter Variants Are Associated with Prostate Cancer Predisposing Alterations in Benign Prostatic Hyperplasia Patients.丝氨酸蛋白酶抑制剂Kazal型1（SPINK1）启动子变异与良性前列腺增生患者前列腺癌易感性改变相关。
Anticancer Res. 2015 Jul;35(7):3811-9.
6
Promoter Polymorphism (rs12770170, -184C/T) of Microseminoprotein, Beta as a Risk Factor for Benign Prostatic Hyperplasia in Korean Population.微精囊蛋白β启动子多态性(rs12770170，-184C/T)与韩国人群良性前列腺增生的相关性研究。
Int Neurourol J. 2014 Jun;18(2):63-7. doi: 10.5213/inj.2014.18.2.63. Epub 2014 Jun 26.

本文引用的文献

1
Genetic variations in VDR associated with prostate cancer risk and progression in a Korean population.维生素 D 受体基因多态性与韩国人群前列腺癌发病风险及进展的相关性
Gene. 2014 Jan 1;533(1):86-93. doi: 10.1016/j.gene.2013.09.119. Epub 2013 Oct 9.
2
Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation.谷胱甘肽化脂质醛是脂肪细胞氧化应激的产物，也是巨噬细胞炎症的激活剂。
Diabetes. 2014 Jan;63(1):89-100. doi: 10.2337/db13-0777. Epub 2013 Sep 23.
3
Association between aldehyde dehydrogenase 2 polymorphisms and the incidence of diabetic retinopathy among Japanese subjects with type 2 diabetes mellitus.醛脱氢酶 2 多态性与日本 2 型糖尿病患者糖尿病视网膜病变发生率的关系。
Cardiovasc Diabetol. 2013 Sep 13;12:132. doi: 10.1186/1475-2840-12-132.
4
Prostate volume correlates with diabetes in elderly benign prostatic hyperplasia patients.老年良性前列腺增生患者的前列腺体积与糖尿病相关。
Int Urol Nephrol. 2014 Mar;46(3):499-504. doi: 10.1007/s11255-013-0555-3.
5
Characterization and clinical relevance of ALDHbright populations in prostate cancer.前列腺癌中 ALDHbright 群体的特征及临床相关性。
Clin Cancer Res. 2013 Oct 1;19(19):5361-71. doi: 10.1158/1078-0432.CCR-12-2857. Epub 2013 Aug 22.
6
Validation of association of genetic variants at 10q with prostate-specific antigen (PSA) levels in men at high risk for prostate cancer.验证与前列腺癌高危男性的前列腺特异性抗原（PSA）水平相关的 10q 基因变异的关联性。
BJU Int. 2014 May;113(5b):E150-6. doi: 10.1111/bju.12264. Epub 2013 Aug 13.
7
The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and the number of components of metabolic syndrome.下尿路症状/良性前列腺增生与代谢综合征成分数量之间的关系。
Urology. 2013 Sep;82(3):674-9. doi: 10.1016/j.urology.2013.03.047. Epub 2013 Jul 11.
8
Subchronic exposure to ethyl tertiary butyl ether resulting in genetic damage in Aldh2 knockout mice.亚慢性乙基叔丁基醚暴露导致 Aldh2 敲除小鼠遗传损伤。
Toxicology. 2013 Sep 15;311(3):107-14. doi: 10.1016/j.tox.2013.06.005. Epub 2013 Jun 25.
9
Report on a patient with a 12q24.31 microdeletion inherited from an insulin-dependent diabetes mellitus father.一名从患有胰岛素依赖型糖尿病的父亲遗传了12号染色体长臂24.31微缺失的患者报告。
Mol Syndromol. 2013 Mar;4(3):136-42. doi: 10.1159/000346473. Epub 2013 Jan 15.
10
The role of chronic prostatic inflammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH).慢性前列腺炎症在良性前列腺增生（BPH）的发病机制和进展中的作用。
BJU Int. 2013 Aug;112(4):432-41. doi: 10.1111/bju.12118. Epub 2013 Apr 12.

韩国人群中 ALDH2 错义单核苷酸多态性（Glu504Lys）与良性前列腺增生的关联。

Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population.

机构信息

Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.

Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.

出版信息

Int Neurourol J. 2013 Dec;17(4):168-73. doi: 10.5213/inj.2013.17.4.168. Epub 2013 Dec 31.

DOI:10.5213/inj.2013.17.4.168
PMID:24466463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3895508/
Abstract

PURPOSE

Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH.

METHODS

A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed.

RESULTS

The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05).

CONCLUSION

We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.

摘要

目的

醛脱氢酶 2（ALDH2）是参与酒精和醛代谢的知名基因。此外，最近的研究报告称 ALDH2 与与年龄相关的疾病之间存在关联。良性前列腺增生（BPH）是一种与年龄相关的疾病，遗传因素可能促成其发病。在这项研究中，我们调查了研究充分的 ALDH2 单核苷酸多态性（SNP）rs671 与 BPH 发病和临床特征的关系。

方法

对 222 名 BPH 患者和 214 名对照进行基因分型。分析 BPH 患者的临床特征（前列腺体积、前列腺特异性抗原水平和国际前列腺症状评分）。

结果

结果表明，rs671 仅与基因型和等位基因频率的 BPH 体积相关（P<0.05）。

结论

我们提出 rs671 是 ALDH2 中的一个亚洲特异性 SNP，可能影响韩国人群中 BPH 的疾病进展。