Wu Hemmings, van Kuyck Kris, Tambuyzer Tim, Luyten Laura, Aerts Jean-Marie, Nuttin Bart
Research Group Experimental Neurosurgery and Neuroanatomy, KU Leuven, Leuven, Belgium.
M3-BIORES: Measure, Model & Manage Bioresponses, Department of Biosystems, KU Leuven, Leuven, Belgium.
Sci Rep. 2014 Jan 29;4:3929. doi: 10.1038/srep03929.
When a rat is on a limited fixed-time food schedule with full access to a running wheel (activity-based anorexia model, ABA), its activity level will increase hours prior to the feeding period. This activity, called food-anticipatory activity (FAA), is a hypothesized parallel to the hyperactivity symptom in human anorexia nervosa. To investigate in depth the characteristics of FAA, we retrospectively analyzed the level of FAA and activities during other periods in ABA rats. To our surprise, rats with the most body weight loss have the lowest level of FAA, which contradicts the previously established link between FAA and the severity of ABA symptoms. On the contrary, our study shows that postprandial activities are more directly related to weight loss. We conclude that FAA alone may not be sufficient to reflect model severity, and activities during other periods may be of potential value in studies using ABA model.
当一只大鼠按照有限的固定时间进食计划进食，同时可以自由使用跑步轮（基于活动的厌食模型，ABA）时，其活动水平会在进食期前数小时增加。这种活动被称为食物预期活动（FAA），据推测它与人类神经性厌食症中的多动症状相似。为了深入研究FAA的特征，我们回顾性分析了ABA大鼠中FAA的水平以及其他时间段的活动情况。令我们惊讶的是，体重减轻最多的大鼠FAA水平最低，这与之前确立的FAA与ABA症状严重程度之间的联系相矛盾。相反，我们的研究表明餐后活动与体重减轻更直接相关。我们得出结论，仅FAA可能不足以反映模型的严重程度，在使用ABA模型的研究中，其他时间段的活动可能具有潜在价值。
