通过定义可靠的皮质脊髓兴奋性估计值来优化经颅磁刺激方案。
Optimization of the transcranial magnetic stimulation protocol by defining a reliable estimate for corticospinal excitability.
机构信息
REVAL Rehabilitation Research Centre, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium ; Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, Department of Biomedical Kinesiology, Group Biomedical Sciences, K.U. Leuven, Heverlee, Belgium.
I-BioStat, Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium ; I-BioStat, Interuniversity Institute for Biostatistics and statistical Bioinformatics, Leuven University, Leuven, Belgium.
出版信息
PLoS One. 2014 Jan 24;9(1):e86380. doi: 10.1371/journal.pone.0086380. eCollection 2014.
The goal of this study was to optimize the transcranial magnetic stimulation (TMS) protocol for acquiring a reliable estimate of corticospinal excitability (CSE) using single-pulse TMS. Moreover, the minimal number of stimuli required to obtain a reliable estimate of CSE was investigated. In addition, the effect of two frequently used stimulation intensities [110% relative to the resting motor threshold (rMT) and 120% rMT] and gender was evaluated. Thirty-six healthy young subjects (18 males and 18 females) participated in a double-blind crossover procedure. They received 2 blocks of 40 consecutive TMS stimuli at either 110% rMT or 120% rMT in a randomized order. Based upon our data, we advise that at least 30 consecutive stimuli are required to obtain the most reliable estimate for CSE. Stimulation intensity and gender had no significant influence on CSE estimation. In addition, our results revealed that for subjects with a higher rMT, fewer consecutive stimuli were required to reach a stable estimate of CSE. The current findings can be used to optimize the design of similar TMS experiments.
本研究旨在优化经颅磁刺激（TMS）方案，以使用单次 TMS 获得皮质脊髓兴奋性（CSE）的可靠估计。此外，还研究了获得可靠 CSE 估计所需的最小刺激数量。此外，评估了两种常用刺激强度[110%相对静息运动阈值（rMT）和 120%rMT]和性别对 CSE 估计的影响。36 名健康年轻受试者（18 名男性和 18 名女性）参加了一项双盲交叉程序。他们以随机顺序接受 2 个 40 个连续 TMS 刺激的块，分别为 110%rMT 或 120%rMT。根据我们的数据，我们建议至少需要 30 个连续刺激才能获得最可靠的 CSE 估计。刺激强度和性别对 CSE 估计没有显著影响。此外，我们的结果表明，对于 rMT 较高的受试者，需要较少的连续刺激即可达到稳定的 CSE 估计。当前的研究结果可用于优化类似 TMS 实验的设计。
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