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Serum Lp(a) in diabetics with and without evidence of clinical nephropathy-A preliminary study.有和无临床肾病证据的糖尿病患者的血清脂蛋白（a）——一项初步研究
Indian J Clin Biochem. 2002 Jan;17(1):45-8. doi: 10.1007/BF02867941.
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The effect of N-acetylcysteine on proteinuria and markers of tubular injury in non-diabetic patients with chronic kidney disease. A placebo-controlled, randomized, open, cross-over study.N-乙酰半胱氨酸对非糖尿病慢性肾脏病患者蛋白尿及肾小管损伤标志物的影响。一项安慰剂对照、随机、开放、交叉研究。
Kidney Blood Press Res. 2008;31(6):404-10. doi: 10.1159/000185828. Epub 2008 Dec 18.
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N-Acetylcysteine prevents but does not reverse dexamethasone-induced hypertension.N-乙酰半胱氨酸可预防但不能逆转地塞米松诱导的高血压。
Clin Exp Pharmacol Physiol. 2008 Aug;35(8):979-81. doi: 10.1111/j.1440-1681.2008.04947.x. Epub 2008 Apr 21.
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Long-term N-acetylcysteine and L-arginine administration reduces endothelial activation and systolic blood pressure in hypertensive patients with type 2 diabetes.长期给予N-乙酰半胱氨酸和L-精氨酸可降低2型糖尿病高血压患者的内皮激活和收缩压。
Diabetes Care. 2008 May;31(5):940-4. doi: 10.2337/dc07-2251. Epub 2008 Feb 11.
6
Association of Early Atherosclerotic Vascular Changes with Serum Lipoprotein (a) in Predialysis Chronic Renal Failure and Maintenance Hemodialysis Patients.透析前慢性肾衰竭和维持性血液透析患者早期动脉粥样硬化血管变化与血清脂蛋白(a)的关系
Saudi J Kidney Dis Transpl. 2005 Apr-Jun;16(2):154-60.
7
Prospective study of lipoprotein(a) as a risk factor for deteriorating renal function in type 2 diabetic patients with overt proteinuria.脂蛋白(a)作为2型糖尿病显性蛋白尿患者肾功能恶化危险因素的前瞻性研究。
Diabetes Care. 2005 Jul;28(7):1718-23. doi: 10.2337/diacare.28.7.1718.
8
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Diabetic nephropathy: diagnosis, prevention, and treatment.糖尿病肾病：诊断、预防与治疗
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10
Five cysteine-containing compounds have antioxidative activity in Balb/cA mice.五种含半胱氨酸的化合物在Balb/cA小鼠中具有抗氧化活性。
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N-乙酰半胱氨酸对2型糖尿病患者血清脂蛋白（a）和蛋白尿的影响。

Effects of N-acetyl cysteine on serum lipoprotein (a) and proteinuria in type 2 diabetic patients.

作者信息

Rouhi Hamid, Ganji Forouzan

机构信息

Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.

出版信息

J Nephropathol. 2013 Jan;2(1):61-6. doi: 10.5812/nephropathol.8940. Epub 2013 Jan 1.

DOI:10.5812/nephropathol.8940
PMID:24475426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3886171/
Abstract

BACKGROUND

About 30-40% of diabetic patients who developed nephropathy have lipoprotein disorders, especially lipoprotein a [Lp(a)], which is related to atherosclerosis.

OBJECTIVES

The aim of this study was to investigate the effect of N-acetyl cysteine (NAC) on the serum levels of Lp(a) and amount of proteinuria in a group of type 2 diabetic patients with diabetic nephropathy.

PATIENTS AND METHODS

A total of 40, type 2 diabetic (T2D) patients, patients with proteinuria, were randomly divided into two groups. The experimental group was treated by NAC (1200 mg/day) for two months in conjunction with conventional treatment for diabetes and hypertension. Control group received routine medications.

RESULTS

No significant change was identified in serum Lp(a) during treatment with NAC (P >0.05). However, NAC decreased the amount of proteinuria, serum triglyceride (TG) level and systolic blood pressure in experimental group compared to the control group (P <0.05).

CONCLUSIONS

These findings suggest that treatment with NAC has no significant effect on the serum level of Lp (a). However, it has beneficial effects on the reduction of proteinuria, serum TG level and systolic blood pressure in T2D patients with nephropathy. Further prospective studies are needed to determine its full role.

摘要

背景

在发生肾病的糖尿病患者中，约30%-40%存在脂蛋白紊乱，尤其是脂蛋白a[Lp(a)]，其与动脉粥样硬化有关。

目的

本研究旨在探讨N-乙酰半胱氨酸（NAC）对一组2型糖尿病肾病患者血清Lp(a)水平及蛋白尿含量的影响。

患者与方法

共有40例有蛋白尿的2型糖尿病（T2D）患者被随机分为两组。实验组在接受糖尿病和高血压常规治疗的同时，接受NAC（1200毫克/天）治疗两个月。对照组接受常规药物治疗。

结果

在使用NAC治疗期间，血清Lp(a)无显著变化（P>0.05）。然而，与对照组相比，实验组的NAC降低了蛋白尿含量、血清甘油三酯（TG）水平和收缩压（P<0.05）。

结论

这些发现表明，NAC治疗对血清Lp(a)水平无显著影响。然而，它对降低2型糖尿病肾病患者蛋白尿、血清TG水平和收缩压有有益作用。需要进一步的前瞻性研究来确定其全部作用。