aMcGowan Institute for Regenerative Medicine bDepartment of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Curr Opin Organ Transplant. 2014 Apr;19(2):169-74. doi: 10.1097/MOT.0000000000000050.
This review outlines the concept of cell-based therapy to restore tissue function, and addresses four key points to consider in cell transplantation: source, surveillance, safety, and site. Whereas each point is essential, additional attention should be given to transplantation sites if cell therapy is going to be successful in the clinic. Various ectopic locations are discussed, and the strengths and weaknesses of each are compared as suitable candidates for cell therapy.
Studies in rodents often demonstrate cell transplantation and engraftment in ectopic sites, with little evidence to suggest why it may also work in humans. For example, transplantation to the subcapsular space of the kidney is often performed in rodents, but has not been a good predictor of clinical success. Recent work has shown that the lymph node may be a good site for transplantation of multiple tissue types, and several reasons are highlighted as to why it should be considered for future studies.
The use of cell-based therapy in the clinic has been hampered by the lack of appropriate sites for transplantation. The lymph node is a promising alternative for cell transplantation, and offers hope for clinical application.
本综述概述了基于细胞的疗法来恢复组织功能的概念，并提出了细胞移植时需要考虑的四个关键要点：来源、监测、安全性和部位。虽然每个要点都很重要，但如果细胞疗法要在临床上取得成功，那么对移植部位应给予更多关注。本文讨论了各种异位部位，并比较了每个部位作为细胞治疗候选部位的优缺点。
在啮齿动物中的研究经常表明细胞在异位部位的移植和植入，而很少有证据表明为什么它在人类中也能奏效。例如，将细胞移植到肾脏的被膜下腔在啮齿动物中经常进行，但并不能很好地预测临床疗效。最近的研究表明，淋巴结可能是多种组织类型移植的良好部位，并强调了为什么应该考虑将其用于未来的研究。
细胞疗法在临床上的应用受到缺乏合适的移植部位的限制。淋巴结是细胞移植的一个很有前途的选择，为临床应用带来了希望。
