From the aCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; bMunicipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain; cCIBER Epidemiología y SaludPública (CIBERESP), Barcelona, Spain; dParc de Salut Mar, Obstetrics and Gynecology Department, Barcelona, Spain; eNational Institute of Health and Medical Research (INSERM), Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institute Albert Bonniot, Grenoble, France; fBiodetection Systems B.V., Amsterdam, The Netherlands; gDepartment of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece; hCentre for Epidemiology and Biostatistics, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, United Kingdom; iBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, United Kingdom; jSection of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; kFaculty of Health and Life sciences, Pompeu Fabra University, Barcelona, Spain; lDepartment of Pediatrics, Obstetrics and Gynecology and Preventive Medicine, Faculty of Medicine, Autonomous University of Barcelona, Barcelona, Spain; mDepartment of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; nDepartment of Food, Water and Cosmetics, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway; oDepartment of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; pInstitute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece; qDepartment of Biosciences and Nutrition, Unit of Molecular Epidemiology, Karolinska Institute, Huddinge, Sweden; rEpidemiology, Biostatistics, and Clinical Trials, IRCCS AOU San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy; sDepartme
Epidemiology. 2014 Mar;25(2):215-24. doi: 10.1097/EDE.0000000000000046.
Maternal exposure to dioxins and dioxin-like compounds may affect fetal growth and development. We evaluated the association between in utero dioxin-like activity and birth outcomes in a prospective European mother-child study.
We measured dioxin-like activity in maternal and cord blood plasma samples collected at delivery using the Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) bioassay in 967 mother-child pairs, in Denmark, Greece, Norway, Spain, and England. Multiple linear regression models were used to investigate the associations with birth weight, gestational age, and head circumference.
Plasma dioxin-like activity was higher in maternal sample than in cord samples. Birth weight was lower with medium (-58 g [95% confidence interval (CI) = -176 to 62]) and high (-82 g [-216 to 53]) tertiles of exposure (cord blood) compared with the lowest tertile. Gestational age was shorter by approximately half a week in the highest compared with the lowest (-0.4 weeks [95% CI = -0.8 to -0.1]). This association was stronger in boys than in girls, although the statistical evidence for interaction was weak (P = 0.22). Analysis based on CALUX-toxic equivalents expressed per milliliter of plasma showed similar trends. We found no association between dioxin-like activity in maternal plasma and birth outcomes.
Results from this international general population study suggest an association between low-level prenatal dioxin-like activity and shorter gestational age, particularly in boys, with weaker associations for birth weight.
母体暴露于二恶英和类二恶英化合物可能会影响胎儿的生长和发育。我们评估了在一项前瞻性欧洲母婴研究中宫内类二恶英活性与出生结局之间的关联。
我们使用 Dioxin-Responsive Chemically Activated LUciferase eXpression (DR CALUX) 生物测定法，在丹麦、希腊、挪威、西班牙和英国的 967 对母婴中，测量了分娩时采集的母血和脐血血浆样本中的类二恶英活性。我们使用多元线性回归模型来研究与出生体重、胎龄和头围的关联。
母血样本中的类二恶英活性高于脐血样本。与最低三分位相比，中三分位（-58g[95%置信区间（CI）=-176 至 62]）和高三分位（-82g[-216 至 53]）的暴露（脐血）使出生体重降低。与最低三分位相比，最高三分位的胎龄缩短了大约半周（-0.4 周[95%CI=-0.8 至-0.1]）。尽管交互作用的统计证据较弱（P=0.22），但这种关联在男孩中比在女孩中更强。基于每毫升血浆表示的 CALUX 毒性当量的分析显示出类似的趋势。我们没有发现母体血浆中类二恶英活性与出生结局之间的关联。
这项国际一般人群研究的结果表明，低水平的产前类二恶英活性与胎龄较短有关，尤其是在男孩中，与出生体重的关联较弱。
