Norberg L E, Lundquist P G
Department of Otolaryngology, Linköping University Hospital, Sweden.
Auris Nasus Larynx. 1988;15(1):1-17. doi: 10.1016/s0385-8146(88)80004-x.
The submandibular glands in 32 rats were exposed to either fractionated irradiation comparable to 50 Gy or a single fraction of 50 Gy. Prior to irradiation half the rats were given cyclocytidine, an alpha-adrenergic agonist which depletes serous cell granules. The results suggest that irradiation causes a significant, irreversible destruction of serous cells. Visible morphological changes were: intracytoplasmic vacuoles, destroyed mitochondria with disrupted cristae and derangement of the endoplasmic reticulum. Animals treated with cyclocytidine had diminished radiation injury. This drug may act as radioprotector, depleting secretory heavy metal granules, reducing radiation damage in the submandibular salivary glands.
将32只大鼠的下颌下腺暴露于相当于50 Gy的分次照射或单次50 Gy照射下。在照射前，给一半的大鼠注射环胞苷，一种能消耗浆液细胞颗粒的α-肾上腺素能激动剂。结果表明，照射会导致浆液细胞发生显著的、不可逆的破坏。可见的形态学变化有：胞浆内空泡、嵴断裂的线粒体破坏以及内质网紊乱。用环胞苷治疗的动物辐射损伤减轻。这种药物可能作为辐射防护剂，消耗分泌性重金属颗粒，减少下颌下唾液腺的辐射损伤。
