灵长类动物眼睑融合后视网膜血管活性肠多肽增加。

Stone R A, Laties A M, Raviola E, Wiesel T N

Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia 19104.

Proc Natl Acad Sci U S A. 1988 Jan;85(1):257-60. doi: 10.1073/pnas.85.1.257.

Lids were fused in six neonatal and one adult macaque monkey (Macaca mulatta and Macaca arctoides) and were kept fused for 1 to 18.5 months. The juvenile macaques, but not the adult one, developed myopia due to excessive elongation of the eye. In all animals, the immunohistochemical reactivity of the retina for vasoactive intestinal polypeptide (VIP) was much higher in the closed than in the open eyes. The neuropeptide was localized to the perikaryon and dendrites of amacrine cells. No difference was observed in substance P immunoreactivity between open and closed eyes, suggesting that the observed effect is selective. The change in VIP immunoreactivity could be the result of an increase in peptide synthesis, a decrease in peptide release, or a combination of the two. These results indicate that VIP may play a part in the regulation of postnatal ocular growth.

在六只新生猕猴和一只成年猕猴（恒河猴和熊猴）中，眼睑被融合，并保持融合状态1至18.5个月。幼年猕猴而非成年猕猴因眼球过度伸长而出现近视。在所有动物中，视网膜对血管活性肠肽（VIP）的免疫组化反应性在闭眼时比睁眼时高得多。该神经肽定位于无长突细胞的胞体和树突。睁眼和闭眼之间在P物质免疫反应性方面未观察到差异，表明观察到的效应具有选择性。VIP免疫反应性的变化可能是肽合成增加、肽释放减少或两者共同作用的结果。这些结果表明，VIP可能在出生后眼球生长的调节中起作用。