Li Yang, Wei Jun, Zhao Zhongxin, You Tiangeng, Zhong Mingan
Department of Gastrointestinal Surgery, East Hospital, Tongji University, 150 Jimo Road, Pudong New District, Shanghai 200120, China.
ScientificWorldJournal. 2013 Dec 30;2013:618670. doi: 10.1155/2013/618670. eCollection 2013.
Pancreaticobiliary maljunction (PBM) has been reported to be associated with an increased risk of gallbladder carcinoma. However, the relationship between PBM and common bile duct carcinoma (CBDC) remains unclear. We aimed to conduct a meta-analysis to determine the available evidence on the association between PBM and CBDC.
The pooled odds ratio (OR) and standard mean differences (SMD) with 95% confidence interval (95% CI) were used to estimate the effects.
A total of eight case-control studies and two cohort studies were identified. The incidence of PBM was higher in CBDC patients than in controls (OR = 1.45; 95% CI, 1.19-1.76). Compared with patients without PBM, CBDC patients with PBM were younger at the diagnosis age (SMD = -0.46; 95% CI, -0.64 to -0.28). A difference in the incidence of associated CDC was found between CBDC patients with or without PBM (OR = 2.14; 95% CI, 1.60-2.87).
Compared with benign biliary tract diseases, the incidence of PBM was higher in CBDC patients, especially in relatively young patients. We also found that the incidence of CDC was higher in CBDC patients with PBM. These findings showed positive association between PBM and CBDC, which may help in identifying high-risk individuals.
据报道，胰胆管合流异常（PBM）与胆囊癌风险增加有关。然而，PBM与胆总管癌（CBDC）之间的关系仍不清楚。我们旨在进行一项荟萃分析，以确定关于PBM与CBDC关联的现有证据。
采用合并比值比（OR）和95%置信区间（95%CI）的标准平均差（SMD）来估计效应。
共纳入八项病例对照研究和两项队列研究。CBDC患者中PBM的发生率高于对照组（OR = 1.45；95%CI，1.19 - 1.76）。与无PBM的患者相比，有PBM的CBDC患者诊断时年龄更小（SMD = -0.46；95%CI，-0.64至-0.28）。有或无PBM的CBDC患者之间相关胆管癌（CDC）的发生率存在差异（OR = 2.14；95%CI，1.60 - 2.87）。
与良性胆道疾病相比，CBDC患者中PBM的发生率更高，尤其是相对年轻的患者。我们还发现，有PBM的CBDC患者中CDC的发生率更高。这些发现表明PBM与CBDC之间存在正相关，这可能有助于识别高危个体。
