Lalwani Gaurav, Cai Xin, Nie Liming, Wang Lihong V, Sitharaman Balaji
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794-5281, USA.
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130, USA.
Photoacoustics. 2013 Dec 1;1(3-4):62-67. doi: 10.1016/j.pacs.2013.10.001.
In this work, graphene nanoribbons and nanoplatelets were investigated as contrast agents for photoacoustic and thermoacoustic tomography (PAT and TAT). We show that oxidized single-and multi-walled graphene oxide nanoribbons (O-SWGNRs, O-MWGNRs) exhibit approximately 5-10 fold signal enhancement for PAT in comparison to blood at the wavelength of 755 nm, and approximately 10-28% signal enhancement for TAT in comparison to deionized (DI) water at 3 GHz. Oxidized graphite microparticles (O-GMPs) and exfoliated graphene oxide nanoplatelets (O-GNPs) show no significant signal enhancement for PAT, and approximately 12-29% signal enhancement for TAT. These results indicate that O-GNRs show promise as multi-modal PAT and TAT contrast agents, and that O-GNPs are suitable contrast agents for TAT.
在这项工作中，研究了石墨烯纳米带和纳米片作为光声和热声断层扫描（PAT和TAT）的造影剂。我们发现，在755 nm波长下，氧化的单壁和多壁氧化石墨烯纳米带（O-SWGNRs、O-MWGNRs）与血液相比，PAT信号增强约5-10倍；在3 GHz下，与去离子水（DI）相比，TAT信号增强约10-28%。氧化石墨微粒（O-GMPs）和剥离的氧化石墨烯纳米片（O-GNPs）对PAT没有显著的信号增强，对TAT的信号增强约为12-29%。这些结果表明，O-GNRs有望成为多模态PAT和TAT造影剂，而O-GNPs是适合TAT的造影剂。
