Burdanova Maria G, Kharlamova Marianna V, Kramberger Christian, Nikitin Maxim P
Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Institutskii Pereulok 9, 141700 Dolgoprudny, Russia.
Department of Physics, Moscow Region State University, Very Voloshinoy Street, 24, 141014 Mytishi, Russia.
Nanomaterials (Basel). 2021 Nov 10;11(11):3020. doi: 10.3390/nano11113020.
This review is dedicated to a comprehensive description of the latest achievements in the chemical functionalization routes and applications of carbon nanomaterials (CNMs), such as carbon nanotubes, graphene, and graphene nanoribbons. The review starts from the description of noncovalent and covalent exohedral modification approaches, as well as an endohedral functionalization method. After that, the methods to improve the functionalities of CNMs are highlighted. These methods include the functionalization for improving the hydrophilicity, biocompatibility, blood circulation time and tumor accumulation, and the cellular uptake and selectivity. The main part of this review includes the description of the applications of functionalized CNMs in bioimaging, drug delivery, and biosensors. Then, the toxicity studies of CNMs are highlighted. Finally, the further directions of the development of the field are presented.
本综述致力于全面描述碳纳米材料（CNMs），如碳纳米管、石墨烯和石墨烯纳米带的化学功能化路线及应用方面的最新成果。综述首先描述了非共价和共价外表面修饰方法以及一种内表面功能化方法。之后，着重介绍了提高碳纳米材料功能的方法。这些方法包括用于改善亲水性、生物相容性、血液循环时间和肿瘤积累以及细胞摄取和选择性的功能化。本综述的主要部分包括对功能化碳纳米材料在生物成像、药物递送和生物传感器方面应用的描述。然后，着重介绍了碳纳米材料的毒性研究。最后，给出了该领域进一步的发展方向。
