Department of Ophthalmology .
Ocul Immunol Inflamm. 2014 Feb;22(1):34-41. doi: 10.3109/09273948.2012.752507.
To compare the cytokine spectrum of vitreoretinal lymphoma to uveitis and correlate cytokine concentrations with disease activity.
Retrospective case series of 10 patients with vitreoretinal lymphoma and 7 patients with uveitis. Aqueous humor concentration of IFN-γ, TNF-α, TNF-β, IL-1ra, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, MCP-1, G-CSF, GM-CSF, and VEGF-A was determined using a bead-based assay (Luminex). Variance between groups, correlation coefficients, and longitudinal behavior of cytokines were analyzed.
No statistically significant difference in cytokines was found when comparing groups. IL-10 was positively correlated with IL-6 and MCP-1. IL-6 was positively correlated with G-CSF, IL-1ra, IL-8, and IL-10. A relationship between concentration of any cytokine, aside from IL-10, and disease activity was not found.
IL-10 and IL-6 are good immunologic markers to be used as complementary diagnostic tools. IL-10 is the only IL that could be used for monitoring purposes.
比较脉络膜视网膜淋巴瘤与葡萄膜炎的细胞因子谱，并将细胞因子浓度与疾病活动相关联。
回顾性分析了 10 例脉络膜视网膜淋巴瘤患者和 7 例葡萄膜炎患者。采用基于珠的检测方法（Luminex）测定房水中 IFN-γ、TNF-α、TNF-β、IL-1ra、IL-1β、IL-2、IL-4、IL-5、IL-6、IL-7、IL-8、IL-10、IL-12、IL-13、IL-17、MCP-1、G-CSF、GM-CSF 和 VEGF-A 的浓度。分析了组间方差、相关系数和细胞因子的纵向行为。
比较各组时，细胞因子无统计学差异。IL-10 与 IL-6 和 MCP-1 呈正相关。IL-6 与 G-CSF、IL-1ra、IL-8 和 IL-10 呈正相关。除了 IL-10 之外，任何细胞因子的浓度与疾病活动之间都没有关系。
IL-10 和 IL-6 是很好的免疫标志物，可作为补充诊断工具。IL-10 是唯一可用于监测目的的 IL。
