Fredericks W R, Rapoport S I
Laboratory of Neurosciences, National Institute on Aging, Bethesda, MD 20892.
Stroke. 1988 Feb;19(2):266-8. doi: 10.1161/01.str.19.2.266.
Unilateral reversible osmotic opening of the blood-brain barrier can be produced in mice. Infusion of 1.8 molal arabinose in water at a rate of 0.64 ml/min for 30 seconds into the internal carotid artery consistently results in ipsilateral brain staining by intravascular Evans blue dye. Osmotic opening is concentration-dependent (threshold, 1.6 molal arabinose) and reversible within 4 hours. No long-term neurologic deficit occurs. These results suggest that reversible osmotic blood-brain barrier opening can be applied to disease models in mice.
在小鼠中可产生血脑屏障的单侧可逆性渗透开放。以0.64毫升/分钟的速率将1.8摩尔浓度的阿拉伯糖水溶液注入小鼠颈内动脉30秒，可使血管内伊文思蓝染料持续对同侧脑进行染色。渗透开放具有浓度依赖性（阈值为1.6摩尔浓度的阿拉伯糖），并在4小时内可逆。不会出现长期神经功能缺损。这些结果表明，可逆性渗透性血脑屏障开放可应用于小鼠疾病模型。
