缓冲对颜面部局部麻醉的疼痛及持续时间的影响：一项双盲随机对照试验。
The effect of buffering on pain and duration of local anesthetic in the face: A double-blind, randomized controlled trial.
作者信息
Afolabi Oluwatola, Murphy Amanda, Chung Bryan, Lalonde Donald H
机构信息
Division of Plastic Surgery, Dalhousie University, Halifax, Nova Scotia.
出版信息
Can J Plast Surg. 2013 Winter;21(4):209-12.
BACKGROUND
The acidity of lidocaine preparations is believed to contribute to the pain of local anesthetic injection.
OBJECTIVE
To investigate the effect of buffering lidocaine on the pain of injection and duration of anesthetic effect.
METHODS
A double-blind, randomized trial involving 44 healthy volunteers was conducted. The upper lip was injected with a solution of: lidocaine 1% (Xylocaine, AstraZeneca, Canada, Inc) with epinephrine; and lidocaine 1% with epinephrine and 8.4% sodium bicarbonate. Volunteers reported pain of injection and duration of anesthetic effect.
RESULTS
Twenty-six participants found the unbuffered solution to be more painful. Fifteen participants found the buffered solution to be more painful; the difference was not statistically significant. Twenty-one volunteers reported duration of anesthetic effect. The buffered solution provided longer anesthetic effect than the unbuffered solution (P=0.004).
CONCLUSION
Although buffering increased the duration of lidocaine's anesthetic effect in this particular model, a decrease in the pain of the injection was not demonstrated, likely due to limitations of the study.
背景
利多卡因制剂的酸度被认为会导致局部麻醉注射疼痛。
目的
研究缓冲利多卡因对注射疼痛和麻醉效果持续时间的影响。
方法
对44名健康志愿者进行了一项双盲随机试验。在上唇注射以下溶液：含肾上腺素的1%利多卡因（赛罗卡因，阿斯利康加拿大公司）；含肾上腺素和8.4%碳酸氢钠的1%利多卡因。志愿者报告注射疼痛和麻醉效果持续时间。
结果
26名参与者发现未缓冲溶液更痛。15名参与者发现缓冲溶液更痛；差异无统计学意义。21名志愿者报告了麻醉效果持续时间。缓冲溶液比未缓冲溶液提供了更长的麻醉效果（P=0.004）。
结论
尽管在这个特定模型中缓冲增加了利多卡因的麻醉效果持续时间，但未证明注射疼痛有所减轻，可能是由于研究的局限性。
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