Trost Barry M, Maulide Nuno, Livingston Robert C
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA.
J Am Chem Soc. 2008 Dec 10;130(49):16502-3. doi: 10.1021/ja807696e.
The Ruthenium catalyzed, atom-economical domino redox isomerisation/cyclization of tethered aminopropargyl alcohols is reported. This process displays a broad scope and functional group tolerance. Furthermore, it presents a novel retrosynthetic disconnection linking simple and easily available, linear propargyl alcohols with added-value nitrogen heterocycles in a single catalytic step.
据报道，钌催化的、原子经济的多米诺氧化还原异构化/环化反应可用于连接的氨基炔丙醇。该过程具有广泛的适用范围和官能团耐受性。此外，它还展示了一种新颖的逆合成切断方式，能在单一催化步骤中将简单且易于获得的线性炔丙醇与具有附加值的氮杂环连接起来。
