Rodrigues Helena Sofia, Monteiro M Teresa T, Torres Delfim F M
Math Biosci. 2014 Jan;247:1-12. doi: 10.1016/j.mbs.2013.10.006.
As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of distributing the vaccines investigated: pediatric and random mass vaccines, with distinct levels of efficacy and durability. In a second step, the vaccination is seen as a control variable in the epidemiological process. In both cases, epidemic and endemic scenarios are included in order to analyze distinct outbreak realities.
随着登革热疫苗研发工作的持续推进，我们模拟了一种假设的疫苗，作为对人群的额外保护措施。在第一阶段，将疫苗接种过程作为模型中的一个新隔间进行研究，并探讨了不同的疫苗分配方式：儿童疫苗和随机大规模疫苗，其效力和持久性水平各不相同。在第二步中，将疫苗接种视为流行病学过程中的一个控制变量。在这两种情况下，都纳入了流行和地方病情景，以便分析不同的疫情实际情况。
