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带记忆、再感染和疫苗接种效应的登革热传播动力学的定性分析。

Qualitative Analysis of the Transmission Dynamics of Dengue with the Effect of Memory, Reinfection, and Vaccination.

机构信息

International Intercollegiate Ph.D. Program, National Tsing Hua University, Hsinchu 30013, Taiwan.

Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445, Taiwan.

出版信息

Comput Math Methods Med. 2022 Sep 19;2022:7893570. doi: 10.1155/2022/7893570. eCollection 2022.

Abstract

Dengue fever has a huge impact on people's physical, social, and economic lives in low-income locations worldwide. Researchers use epidemic models to better understand the transmission patterns of dengue fever in order to recommend effective preventative measures and give data for vaccine and treatment development. We use fractional calculus to organise the transmission phenomena of dengue fever, including immunisation, reinfection, therapy, and asymptotic carriers. In addition, we focused our study on the dynamical behavior and qualitative approach of dengue infection. The existence and uniqueness of the solution of the suggested dengue dynamics are inspected through the fixed point theorems of Schaefer and Banach. The Ulam-Hyers stability of the suggested dengue model is established. To illustrate the contribution of the input factors on the system of dengue infection, the solution paths are studied using the Laplace Adomian decomposition approach. Furthermore, numerical simulations are used to show the effects of fractional-order, immunity loss, vaccination, asymptotic fraction, biting rate, and therapy. We have established that asymptomatic carriers, bite rates, and immunity loss rates are all important factors that might make controlling more challenging. The intensity of dengue fever may be controlled by reducing mosquito bite rates, whereas the asymptotic fraction is risky and can transmit the illness to noninfected regions. Vaccination, fractional order, index of memory, and medication can be employed as proper control parameters.

摘要

登革热在全球低收入地区对人们的身体、社会和经济生活产生了巨大影响。研究人员使用传染病模型来更好地了解登革热的传播模式,以便推荐有效的预防措施,并为疫苗和治疗开发提供数据。我们使用分数微积分来组织登革热的传播现象,包括免疫、再感染、治疗和渐近携带者。此外,我们专注于登革热感染的动态行为和定性方法的研究。通过 Schaefer 和 Banach 的不动点定理检查所提出的登革热动力学的解的存在性和唯一性。建立了所提出的登革热模型的 Ulam-Hyers 稳定性。为了说明输入因素对登革热感染系统的贡献,使用拉普拉斯 Adomian 分解方法研究了解的路径。此外,还进行了数值模拟以显示分数阶、免疫丧失、疫苗接种、渐近分数、叮咬率和治疗的影响。我们已经确定,无症状携带者、叮咬率和免疫丧失率都是可能使控制更加困难的重要因素。降低蚊子叮咬率可以控制登革热的强度,而渐近分数是有风险的,可能会将疾病传播到未感染地区。疫苗接种、分数阶、记忆指数和药物可以作为适当的控制参数。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b98/9553356/97c50bc68fd4/CMMM2022-7893570.001.jpg

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