Meadway Alexander, Girkin Christopher A, Zhang Yuhua
Opt Express. 2013 Dec 2;21(24):29792-807. doi: 10.1364/OE.21.029792.
An adaptive optics scanning laser ophthalmoscope (AO-SLO) is adapted to provide optical coherence tomography (OCT) imaging. The AO-SLO function is unchanged. The system uses the same light source, scanning optics, and adaptive optics in both imaging modes. The result is a dual-modal system that can acquire retinal images in both en face and cross-section planes at the single cell level. A new spectral shaping method is developed to reduce the large sidelobes in the coherence profile of the OCT imaging when a non-ideal source is used with a minimal introduction of noise. The technique uses a combination of two existing digital techniques. The thickness and position of the traditionally named inner segment/outer segment junction are measured from individual photoreceptors. In-vivo images of healthy and diseased human retinas are demonstrated.
自适应光学扫描激光检眼镜（AO-SLO）适用于提供光学相干断层扫描（OCT）成像。AO-SLO的功能保持不变。该系统在两种成像模式下使用相同的光源、扫描光学器件和自适应光学器件。其结果是一个双模态系统，能够在单细胞水平上获取视网膜的正面和横截面图像。当使用非理想光源时，开发了一种新的光谱整形方法，以减少OCT成像相干轮廓中的大旁瓣，同时将噪声引入降至最低。该技术结合了两种现有的数字技术。从单个光感受器测量传统上称为内节/外节交界处的厚度和位置。展示了健康和患病人类视网膜的体内图像。
