Li Ai-dong, Tai Jun, Huang Yu-bei, Guo Yong-li, Ge Wen-tong, Zhang Jie, Liu Yuan-hu, Rao Yuan-sheng, Xiao Xiao, Long Ting, Wang Shen, Han Yang, Liu Qiao-yin, Ni Xin
Central Laboratory of Cancer Institute, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100021, China.
Department of Otolaryngology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. Email:
Zhonghua Yi Xue Za Zhi. 2013 Nov 26;93(44):3510-5.
To evaluate the relationship and strength of association for alcohol drinking and tea consumption with the riskS of nasopharynx cancer among Chinese population so as to provide control rationales for nasopharynx cancer in China.
A systematic search of 3 Chinese electronic databases (CNKI, VIP, Wanfang) and 3 English databases (Pubmed, ScienceDirect and SpringerLink) up to March 2013 was performed. Two reviewers independently conducted the literature search, examined eligibility and performed data extraction and quality evaluations. Pooled odd ratio (OR) value and 95%CI value were calculated with random-effects model weighted with inverse of variances.
A total of 14 studies (including 3 cohort and 11 case-control) involving 6559 cases of nasopharynx cancer and 10 567 controls from 6 provinces were included. The pooled OR between alcohol drinking and risks of nasopharynx cancer was 1.12 (95%CI: 0.98-1.26; I(2) = 44.5%, P = 0.037). Compared with the non-drinkers, the risks of nasopharynx cancer for regular drinkers and occasional drinkers were 1.18 (95%CI: 1.00-1.38; I(2) = 0.0%, P = 0.578) and 0.76 (95%CI: 0.65-0.89; I(2) = 33.4%, P = 0.212). And the association of tea consumption with the risks of nasopharynx cancer was 0.53 (95%CI: 0.43-0.60; I(2) = 17.9%, P = 0.301).
In China, occasional alcohol drinking may decrease the risks of nasopharynx cancer while regular drinking elevates the risks. And there is significantly protective effect for tea consumption on the risks of nasopharynx cancer.
评估饮酒和饮茶与中国人群鼻咽癌风险之间的关系及关联强度，为中国鼻咽癌的防控提供依据。
截至2013年3月，系统检索3个中文电子数据库（中国知网、维普、万方）和3个英文数据库（PubMed、ScienceDirect和SpringerLink）。两名评价员独立进行文献检索、资格审查、数据提取和质量评估。采用随机效应模型，以方差倒数加权计算合并比值比（OR）值和95%可信区间（CI）值。
共纳入14项研究（包括3项队列研究和11项病例对照研究），涉及6个省份的6559例鼻咽癌病例和10567例对照。饮酒与鼻咽癌风险的合并OR为1.12（95%CI：0.98 - 1.26；I² = 44.5%，P = 0.037）。与不饮酒者相比，经常饮酒者和偶尔饮酒者患鼻咽癌的风险分别为1.18（95%CI：1.00 - 1.38；I² = 0.0%，P = 0.578）和0.76（95%CI：0.65 - 0.89；I² = 33.4%，P = 0.212）。饮茶与鼻咽癌风险的关联为0.53（95%CI：0.43 - 0.60；I² = 17.9%，P = 0.301）。
在中国，偶尔饮酒可能降低鼻咽癌风险，而经常饮酒则会增加风险。饮茶对鼻咽癌风险有显著的保护作用。
