内源性调节：细胞骨架在跨膜信号转导中的作用。
Regulation from within: the cytoskeleton in transmembrane signaling.
机构信息
Department of Systems Biology, Harvard Medical School, Boston, MA, USA.
出版信息
Trends Cell Biol. 2012 Oct;22(10):515-26. doi: 10.1016/j.tcb.2012.07.006. Epub 2012 Aug 20.
Abstract
There is mounting evidence that the plasma membrane is highly dynamic and organized in a complex manner. The cortical cytoskeleton is proving to be a particularly important regulator of plasmalemmal organization, modulating the mobility of proteins and lipids in the membrane, facilitating their segregation, and influencing their clustering. This organization plays a critical role in receptor-mediated signaling, especially in the case of immunoreceptors, which require lateral clustering for their activation. Based on recent developments, we discuss the structures and mechanisms whereby the cortical cytoskeleton regulates membrane dynamics and organization, and how the nonuniform distribution of immunoreceptors and their self-association may affect activation and signaling.
摘要
越来越多的证据表明，质膜具有高度动态性，并以复杂的方式进行组织。皮质细胞骨架被证明是质膜组织的一个特别重要的调节因子，调节膜中蛋白质和脂质的流动性，促进它们的分隔，并影响它们的聚集。这种组织在受体介导的信号转导中起着关键作用，特别是对于免疫受体，它们的激活需要侧向聚类。基于最近的发展，我们讨论了皮质细胞骨架调节膜动力学和组织的结构和机制，以及免疫受体的非均匀分布及其自身缔合如何影响激活和信号转导。
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