扭曲 A 和 B，来自台湾软珊瑚 Sarcophyton tortuosum 的新二萜类代谢物。
Tortuosenes A and B, new diterpenoid metabolites from the Formosan soft coral Sarcophyton tortuosum.
机构信息
Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
出版信息
Org Lett. 2014 Mar 7;16(5):1314-7. doi: 10.1021/ol403723b. Epub 2014 Feb 13.
Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan soft coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils.
从台湾产软珊瑚 Sarcophyton tortuosum 中分离得到了两种新的二萜类化合物 1 和 2（ Tortuosenes A 和 B），同时还分离得到了一种已知的 cembrane 化合物 emblide（3）。通过广泛的光谱分析确定了 1 和 2 的结构，通过 TDDFT ECD 计算确定了 1 的绝对构型。Tortuosene A 对 N-甲酰基-甲硫氨酸-亮氨酸-苯丙氨酸/细胞松弛素 B（fMLP/CB）诱导的中性粒细胞中超氧阴离子的产生具有显著的抑制作用。
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