Rosecrans Robert, Dohnal James C
NorthShore University HealthSystem, Evanston Hospital, Department of Pathology and Laboratory Medicine, 2650 Ridge Avenue, Evanston, IL 60201, USA.
Clin Biochem. 2014 May;47(7-8):670-2. doi: 10.1016/j.clinbiochem.2014.02.004. Epub 2014 Feb 11.
To investigate seasonal variation of vitamin D levels in 148,821 serum samples during a 2year time period in a northern-latitude city in the United States.
Total vitamin D assay testing by chemiluminescence was performed on the DiaSorin Liaison. Vitamin D results were extracted from the laboratory information system without patient identification during 2011 and 2012 and separated by season and vitamin D results: less than 10ng/mL (deficient), 10-20.0ng/mL (insufficient), 20.1-30ng/mL (borderline), 30.1-40ng/mL (sufficient), 40.1-100ng/mL, and greater than 100ng/mL.
The seasonal winter period constituted the months of January through March; spring, April through June; summer, July through September; and fall, October through December. The data set analyzed included 36,643 samples during the winter, 38,299 in spring, 36,141 in summer, and 37,738 in fall and demonstrated an expected rise and fall in vitamin D levels.
This retrospective epidemiological study demonstrates seasonal variation of vitamin D levels at clinical decision points. Although not unexpected, this variation has an impact on studies relating low vitamin D levels to higher rates of cancer, cardiovascular disease, multiple sclerosis, diabetes, autoimmune disease, and a host of other health risk assessments.
调查美国北部一个城市在两年时间内148,821份血清样本中维生素D水平的季节性变化。
在DiaSorin Liaison上通过化学发光法进行总维生素D检测。在2011年和2012年期间，从实验室信息系统中提取维生素D检测结果，且不涉及患者身份信息，检测结果按季节以及维生素D水平分类如下：低于10ng/mL（缺乏）、10 - 20.0ng/mL（不足）、20.1 - 30ng/mL（临界）、30.1 - 40ng/mL（充足）、40.1 - 100ng/mL以及高于100ng/mL。
季节性冬季包括1月至3月；春季为4月至6月；夏季是7月至9月；秋季为10月至12月。所分析的数据集包括冬季的36,643份样本、春季的38,299份样本、夏季的36,141份样本以及秋季的37,738份样本，结果显示维生素D水平呈现出预期的升降变化。
这项回顾性流行病学研究证明了在临床决策点上维生素D水平存在季节性变化。尽管这并不意外，但这种变化会对那些将低维生素D水平与癌症、心血管疾病、多发性硬化症、糖尿病、自身免疫性疾病以及许多其他健康风险评估联系起来的研究产生影响。
