Iwatsuki K, Chiba S
Arch Int Pharmacodyn Ther. 1980 Dec;248(2):314-21.
The effect of papaverine on the secretion of pancreatic juice in the dog was investigated in preparations of isolated, blood-perfused pancreas. Small doses of papaverine (1-30 microgram) injected intra-arterially did not induce any secretory action. Relatively large doses of papaverine (0.1-1 mg) caused dose-dependent increases in the secretion of pancreatic juice after a delay of a few minutes. The secretory activity of 1 mg of papaverine was approximately equal to that of 0.06 units of secretin. The concentration of bicarbonate in the pancreatic juice induced by papaverine was increased. However, protein concentration was increased slightly. This effect is analogous to that of secretin. Papaverine-induced secretion was not modified by pretreatment with phentolamine, propranolol, atropine, guanethidine and haloperidol. On the other hand, papaverine significantly potentiated the secretion of pancreatic juice induced by secretin. From these results, it is concluded that large doses of papaverine may produce an increase in pancreatic secretion mediated through the increase of intracellular cyclic AMP concentration.
在离体、血液灌注的犬胰腺制备物中，研究了罂粟碱对犬胰液分泌的影响。动脉内注射小剂量罂粟碱（1 - 30微克）未引起任何分泌作用。相对大剂量的罂粟碱（0.1 - 1毫克）在几分钟延迟后导致胰液分泌呈剂量依赖性增加。1毫克罂粟碱的分泌活性约等于0.06单位促胰液素的分泌活性。罂粟碱诱导的胰液中碳酸氢盐浓度升高。然而，蛋白质浓度略有增加。这种作用类似于促胰液素的作用。用酚妥拉明、普萘洛尔、阿托品、胍乙啶和氟哌啶醇预处理后，罂粟碱诱导的分泌未发生改变。另一方面，罂粟碱显著增强了促胰液素诱导的胰液分泌。从这些结果可以得出结论，大剂量罂粟碱可能通过增加细胞内环磷酸腺苷浓度介导胰液分泌增加。
