Malakou Lina S, Gargalionis Antonios N, Piperi Christina, Papadavid Evangelia, Papavassiliou Athanasios G, Basdra Efthimia K
Cellular and Molecular Biomechanics Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Second Department of Dermatology, Medical School, National and Kapodistrian University of Athens, 'Attikon' General University Hospital, Athens, Greece.
Ann Transl Med. 2018 Jun;6(12):245. doi: 10.21037/atm.2018.04.09.
Psoriasis is an immune disease of the skin that frequently develops upon triggering events of mechanical nature and leads to increased proliferation and damaged differentiation of keratinocytes of the epidermis. Mechanical forces are mediated through mechanotransduction, which is the process that translates physical cues into biochemical signaling networks. Latest updates underline the role of mechanotransduction during the acquisition of aberrant properties by the keratinocytes of the skin, therefore implying a potential contribution that promotes psoriasis pathogenesis. The present review discusses the mechano-induced signaling pathways and individual molecules that become activated in psoriasis and in keratinocytes, along with mechano-based putative treatment strategies. We also suggest emerging mechanosensitive molecules for further investigation with potential diagnostic and therapeutic utility in psoriasis.
银屑病是一种皮肤免疫疾病，常因机械性触发事件而发病，导致表皮角质形成细胞增殖增加和分化受损。机械力通过机械转导介导，机械转导是将物理信号转化为生化信号网络的过程。最新研究强调了机械转导在皮肤角质形成细胞获得异常特性过程中的作用，因此暗示其对银屑病发病机制有潜在促进作用。本综述讨论了在银屑病和角质形成细胞中被激活的机械诱导信号通路及单个分子，以及基于机械作用的假定治疗策略。我们还提出了一些新的机械敏感分子，以供进一步研究，它们在银屑病中可能具有诊断和治疗价值。
