着丝粒连接：染色体分离过程中微管连接的形成和调控。
Linked in: formation and regulation of microtubule attachments during chromosome segregation.
机构信息
Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
出版信息
Curr Opin Cell Biol. 2014 Feb;26:113-22. doi: 10.1016/j.ceb.2013.12.005. Epub 2014 Jan 7.
Abstract
Accurate segregation of the replicated genome during cell division depends on dynamic attachments formed between chromosomes and the microtubule polymers of the spindle. Here we review recent advances in mechanistic analysis of microtubule attachment formation and regulation.
摘要
在细胞分裂过程中，准确地分离复制的基因组依赖于染色体与纺锤体微管聚合物之间形成的动态连接。在这里，我们综述了微管连接形成和调控的机制分析方面的最新进展。
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本文引用的文献
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DNA methyltransferase-3-dependent nonrandom template segregation in differentiating embryonic stem cells.DNA 甲基转移酶-3 依赖性非随机模板分离在分化胚胎干细胞中。
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Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.着丝粒驱动蛋白 CENP-E 是一种具有行进性的、双向追踪动态微管末端的蛋白。
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Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.协调相邻结构域介导 TACC3-ch-TOG-网格蛋白组装和有丝分裂纺锤体结合。
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Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.染色体-微管附着的侧向到端向转换需要动力蛋白 CENP-E 和 MCAK。
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Microtubules and Alp7-Alp14 (TACC-TOG) reposition chromosomes before meiotic segregation.微管和 Alp7-Alp14（TACC-TOG）在减数分裂分离前重新定位染色体。
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Chromosome-specific nonrandom sister chromatid segregation during stem-cell division.干细胞分裂过程中染色体特异性的非随机姐妹染色单体分离。
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Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules.长的系绳为 Dam1 环与缩短的微管之间提供高力耦联。
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