棘孢木霉复合群血清阳性在囊性纤维化患者中的影响。
Impact of Scedosporium apiospermum complex seroprevalence in patients with cystic fibrosis.
机构信息
Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Adult Cystic Fibrosis Reference Center, 69495 Pierre-Bénite, France; Université de Lyon, Lyon, France.
L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Institut de Biologie en Santé-IRIS, 49933 Angers, France.
出版信息
J Cyst Fibros. 2014 Dec;13(6):667-73. doi: 10.1016/j.jcf.2014.01.011. Epub 2014 Feb 12.
BACKGROUND
Species of the Scedosporium apiospermum complex (S. a complex) are emerging fungi responsible for chronic airway colonization in cystic fibrosis (CF) patients. Recent studies performed on Aspergillus fumigatus suggest that the colonization of the airways by filamentous fungi may contribute to the progressive deterioration of lung function.
METHODS
We studied S. a complex seroprevalence, as a marker of close contact between patient and the fungi, in a large monocentric cohort of CF patients attended in a reference centre in Lyon, France.
RESULTS
Serum samples from 373 CF patients were analysed. Antibodies against S. a complex were detected in 35 patients (9.4%). In multivariate analysis, S. a complex seropositivity was only associated with seropositivity to A. fumigatus.
CONCLUSIONS
This study does not suggest an association between sensitization against S. a complex and poorer lung function in CF. Prospective studies are needed to evaluate the impact of both seropositivity and S. a complex colonization on the course of CF.
背景
棘孢木霉复合群（Scedosporium apiospermum complex，S. a complex）中的物种是新兴真菌，可导致囊性纤维化（cystic fibrosis，CF）患者慢性气道定植。最近对烟曲霉（Aspergillus fumigatus）的研究表明，丝状真菌对气道的定植可能导致肺功能进行性恶化。
方法
我们在法国里昂的一个参考中心，对一个大型单中心 CF 患者队列进行了研究，检测了棘孢木霉复合群的血清流行率，作为患者与真菌密切接触的标志物。
结果
分析了 373 例 CF 患者的血清样本。35 例（9.4%）患者检测到针对棘孢木霉复合群的抗体。多变量分析表明，棘孢木霉复合群血清阳性仅与烟曲霉血清阳性相关。
结论
本研究未提示 CF 患者中对棘孢木霉复合群的致敏与肺功能下降之间存在关联。需要前瞻性研究来评估血清阳性和棘孢木霉复合群定植对 CF 病程的影响。
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