Department of Microbiology & Immunology, Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
Curr Opin Immunol. 2014 Jun;28:6-11. doi: 10.1016/j.coi.2014.01.003. Epub 2014 Feb 14.
The generation of germinal centers (GCs) is a hallmark feature of the adaptive immune response, resulting in the production of high-affinity antibodies that neutralize pathogens and confer protection upon reinfection. The GC response requires interactions between different immune cell types, and the coordination of complex and dynamic gene expression networks within these cells. Here we provide deeper insights into how microRNAs, small endogenously expressed RNAs, regulate the cellular processes involved in the differentiation and function of T follicular helper cells and germinal center B cells, the two main players of the T cell-dependent humoral immune response.
生发中心（GCs）的产生是适应性免疫反应的一个显著特征，导致产生高亲和力的抗体，中和病原体并在再次感染时提供保护。GC 反应需要不同免疫细胞类型之间的相互作用，以及这些细胞内复杂和动态的基因表达网络的协调。在这里，我们深入了解了 microRNAs（内源性表达的小 RNA）如何调节 T 滤泡辅助细胞和生发中心 B 细胞分化和功能涉及的细胞过程，这两种细胞是 T 细胞依赖性体液免疫反应的两个主要参与者。
