Department of Medical and Pediatric Sciences, Medical Angiology Unit, University of Catania, Catania, Italy.
Department of Bio-medical Sciences, General Pathology and Oncology Section, University of Catania, Catania, Italy.
Int J Mol Med. 2014 Apr;33(4):777-83. doi: 10.3892/ijmm.2014.1657. Epub 2014 Feb 13.
Peripheral arterial disease (PAD) is a manifestation of atherosclerotic vascular disease and is often associated with other comorbidities, such as hypertension, diabetes and dyslipidemia. An increasing body of evidence supports the notion that inflammation plays an important role in the development and progression of PAD. A number of studies have investigated the association of various acute phase proteins, particularly C-reactive protein (CRP), with PAD. Apart from CRP, other circulating biomarkers, such as matrix metalloproteinases (MMPs), selectins and interleukin (IL)-1, IL-2, IL-6, IL-8 and IL-10 have been considered to play a role in the development of PAD. In this review, the role of these circulating biomarkers in PAD is discussed. Current data indicate that the appropriate use of biomarkers in patients with PAD may contribute to an early diagnosis, an enhanced knowledge of the developmental process of the disease, as well as to the subsequent improvement of current therapies and to the development of new ones.
外周动脉疾病（PAD）是动脉粥样硬化血管疾病的一种表现形式，常与其他合并症相关，如高血压、糖尿病和血脂异常。越来越多的证据支持炎症在外周动脉疾病的发生和发展中起重要作用的观点。许多研究已经调查了各种急性期蛋白，特别是 C 反应蛋白（CRP）与 PAD 的关联。除 CRP 外，其他循环生物标志物，如基质金属蛋白酶（MMPs）、选择素和白细胞介素（IL）-1、IL-2、IL-6、IL-8 和 IL-10，也被认为在外周动脉疾病的发生中发挥作用。在这篇综述中，讨论了这些循环生物标志物在外周动脉疾病中的作用。目前的数据表明，在外周动脉疾病患者中适当使用生物标志物可能有助于早期诊断、更好地了解疾病的发展过程，以及随后改进现有的治疗方法和开发新的治疗方法。
