Garibyan Lilit, Sipprell William H, Jalian H Ray, Sakamoto Fernanda H, Avram Mathew, Anderson R Rox
Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Maryland, 02114.
Lasers Surg Med. 2014 Feb;46(2):75-80. doi: 10.1002/lsm.22207. Epub 2013 Dec 3.
Cryolipolysis is a noninvasive and well-tolerated treatment for reduction of localized subcutaneous fat. Although several studies demonstrate the safety and efficacy of this procedure, volumetric fat reduction from this treatment has not been quantified. This prospective study investigated the change in volume of fat after cryolipolysis treatment using three-dimensional (3D) photography.
A prospective study of subjects treated with cryolipolysis on the flank (love handle) was performed at Massachusetts General Hospital. Volume measurements were performed with a Canfield Scientific Vectra three-dimensional camera and software to evaluate the amount of post procedure volume change. Clinical outcomes were assessed with caliper measurements, subject surveys, and blinded physician assessment of photographs.
Eleven subjects were enrolled in this study. Each subject underwent a single cycle of cryolipolysis to one flank. The untreated flank served as an internal control. The follow-up time after treatment was 2 months. The mean amount of calculated absolute fat volume loss using 3D photography from baseline to 2 months follow-up visit was 56.2 ± 25.6 from the treatment site and 16.6 ± 17.6 cc from the control (P < 0.0001). A mean absolute difference of 39.6 cc between the treated and untreated sides was calculated at 2 months post-treatment. Comparison of caliper measurements from baseline to 2 months post-treatment demonstrated significant reduction of the treated flank from 45.6 ± 5.8 mm at baseline to 38.6 ± 4.6 mm at 2 months post-treatment (P < 0.001). The untreated flank did not show significant reduction with caliper measurements demonstrating 45.3 ± 5.0 mm at baseline and 44.6 ± 5.1 mm at 2 months post-treatment (P = 0.360). No unexpected side effects or adverse events were reported. Post-treatment satisfaction surveys demonstrated 82% of subjects were satisfied with the results.
Cryolipolysis is a safe, well-tolerated, and effective noninvasive fat removal methodology that on average leads to 39.6 cc of fat loss of the treated flank at 2 months after a single treatment cycle.
冷冻溶脂术是一种用于减少局部皮下脂肪的非侵入性且耐受性良好的治疗方法。尽管多项研究证明了该手术的安全性和有效性，但这种治疗方法导致的脂肪体积减少尚未得到量化。这项前瞻性研究使用三维（3D）摄影技术调查了冷冻溶脂治疗后脂肪体积的变化。
在马萨诸塞州总医院对接受侧腹（腰间赘肉）冷冻溶脂治疗的受试者进行了一项前瞻性研究。使用Canfield Scientific Vectra三维相机和软件进行体积测量，以评估术后体积变化量。通过卡尺测量、受试者调查以及医生对照片的盲法评估来评估临床结果。
本研究共纳入11名受试者。每位受试者对一侧侧腹进行了一个周期的冷冻溶脂治疗。未治疗的侧腹作为内部对照。治疗后的随访时间为2个月。从基线到2个月随访期，使用3D摄影计算得出的治疗部位绝对脂肪体积平均减少量为56.2±25.6立方厘米，对照部位为16.6±17.6立方厘米（P<0.0001）。治疗后2个月，治疗侧与未治疗侧的平均绝对差值为39.6立方厘米。从基线到治疗后2个月的卡尺测量比较显示，治疗侧腹明显减少，从基线时的45.6±5.8毫米降至治疗后2个月时的38.6±4.6毫米（P<0.001）。未治疗侧腹经卡尺测量未显示明显减少，基线时为45.3±5.0毫米，治疗后2个月时为44.6±5.1毫米（P=0.360）。未报告意外的副作用或不良事件。治疗后满意度调查显示，82%的受试者对结果满意。
冷冻溶脂术是一种安全、耐受性良好且有效的非侵入性脂肪去除方法，在单次治疗周期后2个月，平均可使治疗侧腹减少39.6立方厘米的脂肪。
