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古菌中的蛋白丝氨酸/苏氨酸/酪氨酸磷酸化。

Protein Ser/Thr/Tyr phosphorylation in the Archaea.

机构信息

From the Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061.

出版信息

J Biol Chem. 2014 Apr 4;289(14):9480-7. doi: 10.1074/jbc.R113.529412. Epub 2014 Feb 19.

Abstract

The third domain of life, the Archaea (formerly Archaebacteria), is populated by a physiologically diverse set of microorganisms, many of which reside at the ecological extremes of our global environment. Although ostensibly prokaryotic in morphology, the Archaea share much closer evolutionary ties with the Eukarya than with the superficially more similar Bacteria. Initial genomic, proteomic, and biochemical analyses have revealed the presence of "eukaryotic" protein kinases and phosphatases and an intriguing set of serine-, threonine-, and tyrosine-phosphorylated proteins in the Archaea that may offer new insights into this important regulatory mechanism.

摘要

生命的第三个领域,古菌(以前称为古细菌),居住着一组在生理上多样化的微生物,其中许多微生物存在于我们全球环境的生态极端。尽管古菌在形态上看似原核生物,但它们与真核生物的进化关系比与表面上更相似的细菌更为密切。最初的基因组、蛋白质组和生物化学分析表明,古菌中存在“真核”蛋白激酶和磷酸酶,以及一组有趣的丝氨酸、苏氨酸和酪氨酸磷酸化蛋白,这可能为这一重要的调节机制提供新的见解。

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