在一个喷洒了杀真菌剂的田地以及一名患有侵袭性曲霉病的造血干细胞移植受者的肺部，均分离出带有TR34/L98H突变的耐唑类烟曲霉。
Azole-resistant Aspergillus fumigatus isolate with the TR34/L98H mutation in both a fungicide-sprayed field and the lung of a hematopoietic stem cell transplant recipient with invasive aspergillosis.
作者信息
Rocchi Steffi, Daguindau Etienne, Grenouillet Frédéric, Deconinck Eric, Bellanger Anne-Pauline, Garcia-Hermoso Dea, Bretagne Stéphane, Reboux Gabriel, Millon Laurence
机构信息
Chrono-Environnement UMR 6249 CNRS, Franche-Comté University, Besançon, France.
出版信息
J Clin Microbiol. 2014 May;52(5):1724-6. doi: 10.1128/JCM.03182-13. Epub 2014 Feb 19.
Abstract
A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agricultural areas.
摘要
一名法国农民在造血干细胞移植后发生了由具有TR34/L98H突变的耐唑类烟曲霉引起的侵袭性曲霉病。他曾在喷洒过杀真菌剂的田地工作，在那里采集到了一株与该病例无基因关联的烟曲霉TR34/L98H分离株。如果耐唑类检测增加，在农业地区伏立康唑作为一线治疗药物可能会受到质疑。
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