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本文引用的文献

1
Azole-resistant Aspergillus fumigatus, Iran.伊朗的耐唑类烟曲霉
Emerg Infect Dis. 2013 May;19(5):832-4. doi: 10.3201/eid1905.130075.
2
Voriconazole resistance in Aspergillus fumigatus: should we be concerned?烟曲霉对伏立康唑的耐药性：我们应该担心吗？
Clin Infect Dis. 2013 Aug;57(4):521-3. doi: 10.1093/cid/cit321. Epub 2013 May 10.
3
Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles.烟曲霉所致伏立康唑高度耐药性曲霉菌感染及耐药相关分离株在家庭环境中的重现。
Clin Infect Dis. 2013 Aug;57(4):513-20. doi: 10.1093/cid/cit320. Epub 2013 May 10.
4
Breakthrough pulmonary Aspergillus fumigatus infection with multiple triazole resistance in a Spanish patient with chronic myeloid leukemia.一名西班牙慢性髓性白血病患者发生多重三唑耐药的突破性烟曲霉肺部感染。
Rev Iberoam Micol. 2013 Jan 3;30(1):64-8. doi: 10.1016/j.riam.2012.09.002. Epub 2012 Sep 15.
5
Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany.德国一名急性髓系白血病患者出现唑类耐药的侵袭性曲霉菌病。
Euro Surveill. 2012 Sep 6;17(36):20262.
6
Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus.三唑类杀菌剂可诱导烟曲霉对医用三唑类药物产生交叉耐药性。
PLoS One. 2012;7(3):e31801. doi: 10.1371/journal.pone.0031801. Epub 2012 Mar 1.
7
Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009.2007-2009 年荷兰烟曲霉唑类耐药的临床意义。
Emerg Infect Dis. 2011 Oct;17(10):1846-54. doi: 10.3201/eid1710.110226.
8
Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.在法国血液恶性肿瘤患者接受治疗的队列中，烟曲霉对唑类药物的耐药率较低。
J Antimicrob Chemother. 2011 Feb;66(2):371-4. doi: 10.1093/jac/dkq450. Epub 2010 Dec 5.
9
Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.烟曲霉中唑类耐药与治疗失败相关的频率及演变
Emerg Infect Dis. 2009 Jul;15(7):1068-76. doi: 10.3201/eid1507.090043.
10
Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.烟曲霉中唑类耐药性的出现及单一耐药机制的传播。
PLoS Med. 2008 Nov 11;5(11):e219. doi: 10.1371/journal.pmed.0050219.

在一个喷洒了杀真菌剂的田地以及一名患有侵袭性曲霉病的造血干细胞移植受者的肺部，均分离出带有TR34/L98H突变的耐唑类烟曲霉。

Azole-resistant Aspergillus fumigatus isolate with the TR34/L98H mutation in both a fungicide-sprayed field and the lung of a hematopoietic stem cell transplant recipient with invasive aspergillosis.

作者信息

Rocchi Steffi, Daguindau Etienne, Grenouillet Frédéric, Deconinck Eric, Bellanger Anne-Pauline, Garcia-Hermoso Dea, Bretagne Stéphane, Reboux Gabriel, Millon Laurence

机构信息

Chrono-Environnement UMR 6249 CNRS, Franche-Comté University, Besançon, France.

出版信息

J Clin Microbiol. 2014 May;52(5):1724-6. doi: 10.1128/JCM.03182-13. Epub 2014 Feb 19.

DOI:10.1128/JCM.03182-13
PMID:24554754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3993650/
Abstract

A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agricultural areas.

摘要

一名法国农民在造血干细胞移植后发生了由具有TR34/L98H突变的耐唑类烟曲霉引起的侵袭性曲霉病。他曾在喷洒过杀真菌剂的田地工作，在那里采集到了一株与该病例无基因关联的烟曲霉TR34/L98H分离株。如果耐唑类检测增加，在农业地区伏立康唑作为一线治疗药物可能会受到质疑。