Kuang Yi, Du Xuewen, Zhou Jie, Xu Bing
Brandeis University, 415 South St., MS 015, Waltham, MA, 02453, USA.
Adv Healthc Mater. 2014 Aug;3(8):1217-21. doi: 10.1002/adhm.201300645. Epub 2014 Feb 20.
Self-assembly of small peptide derivatives affords supramolecular nanofibrils that possess characteristic features of amyloid oligomers. Acting as de novo amyloid oligomers, the nanofibrils effectively inhibit the tumor progression both in vitro and in vivo, which demonstrates a new type of anticancer approach and may provide new insights for inverse comorbidity between cancer and neurodegenerative diseases.
小肽衍生物的自组装产生具有淀粉样寡聚体特征的超分子纳米纤维。作为新生的淀粉样寡聚体,这些纳米纤维在体外和体内均能有效抑制肿瘤进展,这展示了一种新型的抗癌方法,并可能为癌症与神经退行性疾病之间的反向共病关系提供新的见解。