Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Biochemistry, Max-Planck Institute for Terrestrial Microbiology, Marburg, Hessen, Germany.
PLoS One. 2014 Feb 26;9(2):e90167. doi: 10.1371/journal.pone.0090167. eCollection 2014.
Studies of the association between excess body weight and risk of meningioma have produced inconsistent results. Therefore, a meta-analysis of published studies was performed to better assess the association between meningioma and excess body weight.
A literature search was conducted in the PubMed and EMBASE databases without any limitations. The reference lists of identified articles were also screened for additional studies. The summary relative risks (RRs) and 95% confidence intervals (CI) were calculated using fixed- or random-effects models.
A total of 6 studies provided risk estimates for overweight or obesity. Overall, the combined RRs were 1.12 (95% CI = 0.98-1.28) for overweight and 1.45 (95% CI = 1.26-1.67) for obesity. After stratification by gender, no significant association was observed for obese men (RR = 1.30, 95% CI = 0.64-2.62), while significant association was detected for obese women (RR = 1.46, 95% CI = 1.26-1.69). No substantial differences emerged across strata of study design and geographic areas.
The results of this meta-analysis suggest that obesity but not overweight is associated with an increased risk of meningioma. Due to the limited number of studies, further research is needed to confirm the association.
超重与脑膜瘤风险之间的相关性研究结果并不一致。因此，我们进行了一项荟萃分析，以更好地评估脑膜瘤与超重之间的相关性。
我们在 PubMed 和 EMBASE 数据库中进行了无限制的文献检索，并对已确定文章的参考文献进行了筛选，以查找其他研究。使用固定效应或随机效应模型计算了汇总相对风险（RR）和 95%置信区间（CI）。
共有 6 项研究提供了超重或肥胖的风险估计值。总体而言，超重的合并 RR 为 1.12（95% CI = 0.98-1.28），肥胖的 RR 为 1.45（95% CI = 1.26-1.67）。按性别分层后，未发现肥胖男性（RR = 1.30，95% CI = 0.64-2.62）存在显著相关性，而肥胖女性（RR = 1.46，95% CI = 1.26-1.69）则存在显著相关性。研究设计和地理区域的分层之间没有出现显著差异。
这项荟萃分析的结果表明，肥胖而非超重与脑膜瘤风险增加有关。由于研究数量有限，需要进一步的研究来确认这种相关性。
