Irimia Andrei, Erhart Matthew J, Brown Timothy T
Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA 90032, USA.
Multimodal Imaging Laboratory, University of California, San Diego, CA 92037, USA; Department of Radiology, University of California, San Diego, CA 92037, USA.
Clin Neurophysiol. 2014 Oct;125(10):1973-84. doi: 10.1016/j.clinph.2014.01.027. Epub 2014 Feb 14.
To assess the feasibility and appropriateness of magnetoencephalography (MEG) for both adult and pediatric studies, as well as for the developmental comparison of these factors across a wide range of ages.
For 45 subjects with ages from 1 to 24years (infants, toddlers, school-age children and young adults), lead fields (LFs) of MEG sensors are computed using anatomically realistic boundary element models (BEMs) and individually-reconstructed cortical surfaces. Novel metrics are introduced to quantify MEG sensor focality.
The variability of MEG focality is graphed as a function of brain volume and cortical area. Statistically significant differences in total cerebral volume, cortical area, MEG global sensitivity and LF focality are found between age groups.
Because MEG focality and sensitivity differ substantially across the age groups studied, the cortical LF maps explored here can provide important insights for the examination and interpretation of MEG signals from early childhood to young adulthood.
This is the first study to (1) investigate the relationship between MEG cortical LFs and brain volume as well as cortical area across development, and (2) compare LFs between subjects with different head sizes using detailed cortical reconstructions.
评估脑磁图（MEG）在成人和儿童研究中的可行性与适用性，以及在广泛年龄范围内对这些因素进行发育比较的情况。
对45名年龄在1至24岁之间的受试者（婴儿、幼儿、学龄儿童和青年），使用解剖学逼真的边界元模型（BEM）和个体重建的皮质表面来计算MEG传感器的导联场（LFs）。引入新的指标来量化MEG传感器的聚焦性。
将MEG聚焦性的变异性绘制成脑容量和皮质面积的函数。发现不同年龄组之间在全脑体积、皮质面积、MEG全局灵敏度和LF聚焦性方面存在统计学上的显著差异。
由于在所研究的年龄组中MEG聚焦性和灵敏度存在显著差异，此处探索的皮质LF图可为从幼儿期到青年期的MEG信号检测和解释提供重要见解。
这是第一项（1）研究发育过程中MEG皮质LF与脑容量以及皮质面积之间关系，以及（2）使用详细的皮质重建比较不同头部大小受试者之间LF的研究。
