Blankenship G W
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, FL 33101.
Ophthalmology. 1988 Feb;95(2):170-7. doi: 10.1016/s0161-6420(88)33212-4.
Fifty eyes with three or four diabetic retinopathy risk factors received argon laser panretinal photocoagulation (PRP) with treatment randomly assigned to either central or peripheral distribution. Six months after treatment, two or more acuity lines had been lost by 24% of the central PRP, and by only 8% of the peripheral PRP eyes. Mean visual field constriction with the I-4e isopter was 39% for the central and 29% for the peripheral PRP eyes; for the IV-4e isopter, it was 12 and 7%. Pretreatment macular thickening increased in 19% of the central PRP eyes, but decreased in 19% of the peripheral PRP eyes (P less than 0.05). There was complete disc neovascular regression in 38% of the central and 47% of the peripheral PRP eyes. Partial regression was obtained in 31% centrally and 33% peripherally treated eyes.
50只患有三到四种糖尿病视网膜病变风险因素的眼睛接受了氩激光全视网膜光凝治疗（PRP），治疗方式随机分配为中央或周边分布。治疗六个月后，接受中央PRP治疗的眼睛中有24%视力下降了两条或更多视力线，而接受周边PRP治疗的眼睛中只有8%出现这种情况。使用I-4e等视线时，中央PRP治疗的眼睛平均视野缩小为39%，周边PRP治疗的眼睛为29%；使用IV-4e等视线时，分别为12%和7%。中央PRP治疗的眼睛中有19%治疗前黄斑增厚，而周边PRP治疗的眼睛中有19%黄斑增厚减轻（P小于0.05）。中央PRP治疗的眼睛中有38%视盘新生血管完全消退，周边PRP治疗的眼睛中有47%完全消退。中央治疗的眼睛中有31%部分消退，周边治疗的眼睛中有33%部分消退。
