Hahn R G
Department of Anaesthesiology, Huddinge University Hospital, Sweden.
Acta Anaesthesiol Scand. 1988 Aug;32(6):493-501. doi: 10.1111/j.1399-6576.1988.tb02773.x.
The relationships between the serum concentrations of amino acids, the volume of irrigating fluid absorbed and symptoms of glycine toxicity were analysed in 18 patients who had undergone transurethral resection of the prostate and in whom intravascular absorption of irrigating fluid containing 2.2% glycine had been recorded. A mean of 7% of the transferred glycine could be detected in the serum within 10 min of irrigant absorption. The half-life of glycine in serum was twice as long when the volume of irrigant absorbed exceeded 1500 ml (100 min; n = 6), and the serum levels of alanine, aminobutyrate, proline and serine were significantly more elevated, than when the volume of irrigant absorbed was between 900 and 1300 ml (n = 6). Where the amount of glycine transferred exceeded 0.5 g.kg-1, symptoms of glycine toxicity developed, their onset coinciding with a rapid increase in the serum levels of non-essential amino acids other than glycine.
对18例接受经尿道前列腺切除术且记录到含2.2%甘氨酸冲洗液血管内吸收的患者，分析了血清氨基酸浓度、冲洗液吸收量与甘氨酸毒性症状之间的关系。在冲洗液吸收后10分钟内，血清中平均可检测到7%输入的甘氨酸。当冲洗液吸收量超过1500 ml时（100分钟；n = 6），甘氨酸在血清中的半衰期延长一倍，且丙氨酸、氨基丁酸、脯氨酸和丝氨酸的血清水平显著高于冲洗液吸收量在900至1300 ml之间时（n = 6）。当输入的甘氨酸量超过0.5 g·kg-1时，出现甘氨酸毒性症状，症状的发作与除甘氨酸外的非必需氨基酸血清水平快速升高同时发生。
